Home / TRANCE/TNFSF11/RANK L / Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein

Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein

Catalog #: 462-TR
88 Citations Datasheet / COA / SDS

Carrier Free

Catalog # Availability Size / Price Qty
462-TR-010/CF

With Carrier

Catalog # Availability Size / Price Qty
462-TR-010
Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein Bioactivity
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Citations (88)
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Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein Summary

Product Specifications

Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to induce osteoclast differentiation of RAW 264.7 mouse monocyte/macrophage cells. The ED50 for this effect is 5‑15 ng/mL in the presence of 2.5 µg/mL of a
cross-linking antibody, Mouse Anti-polyHistidine Monoclonal Antibody (Catalog # MAB050).
An E. coli-expressed Recombinant Mouse (rm) TRANCE (aa 158-317) (Catalog # 462-TEC) is also available. The ED50 for the E. coli-expressed rmTRANCE is 0.5‑2 ng/mL.
Source
Mouse myeloma cell line, NS0-derived mouse TRANCE/TNFSF11/RANK L protein
Arg72-Asp316, with an N-terminal 6-His tag
Accession #
O35235
N-terminal Sequence
Analysis
His
Predicted Molecular Mass
28 kDa
SDS-PAGE
36 kDa, reducing conditions

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462-TR (with carrier)

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462-TR/CF (carrier free)

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COA
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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

462-TR

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 50 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 3 months, 2 to 8 °C under sterile conditions after reconstitution.

462-TR/CF

Formulation Supplied as a 0.2 μm filtered solution in PBS.
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:
  • 3 months from date of receipt, 2 to 8 °C as supplied.

Scientific Data

Bioactivity Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein Bioactivity View Larger

Recombinant Mouse TRANCE/TNFSF11/RANK L (Catalog # 462-TR) induces osteoclast differentiation of the RAW 264.7 mouse monocyte/macrophage cell line. The ED50 for this effect is 5-15 ng/mL in the presence of 2.5 µg/mL of a cross-linking antibody, Mouse Anti-polyHistidine Monoclonal Antibody (Catalog # MAB050)

SDS-PAGE Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein SDS-PAGE View Larger

1 μg/lane of Recombinant Mouse TRANCE/TNFSF11/RANK L was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 36 kDa.

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Reconstitution Calculator

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Background: TRANCE/TNFSF11/RANK L

TRANCE (receptor activator of NF-kappa B ligand [RANK L], also called TNF-related activation-induced cytokines, osteoprotegerin ligand [OPGL], and osteoclast differentiation factor [ODF]), is a member of the tumor necrosis factor (TNF) family. In the TNF superfamily nomenclature, TRANCE is referred to as TNFSF11. TRANCE was originally identified as an immediate early gene upregulated by T cell receptor stimulation. The murine TRANCE cDNA encodes a type II transmembrane protein of 316 amino acids with a predicted cytoplasmic domain of 48 amino acids and an extracellular domain of 247 amino acids. The extracellular domain contains two potential N-linked glycosylation sites. Mouse and human TRANCE share 85% amino acid identity. TRANCE is primarily expressed in T cells and T cell rich organs, such as thymus and lymph nodes. The multi-functions of TRANCE include induction of activation of the c-jun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis, and lymph node organogenesis. RANK is the cell surface signaling receptor of TRANCE. RANK has been shown to undergo receptor clustering during signal transduction. Osteoprotegerin, a soluble member of the TNF receptor family which binds TRANCE, is a naturally occurring decoy receptor that counterbalances the effects of TRANCE.

References
  1. Wong, B.R. et al. (1997) J. Biol. Chem. 272:25190.
  2. Anderson, D.M. et al. (1997) Nature 390:175.
  3. Nakagawa, N. et al. (1998) Biochem. Biophys. Res. Commun. 245:382.
  4. Kong, Y-Y. et al. (1999) Nature 397:315.
Long Name
TNF-related Activation-induced Cytokine
Entrez Gene IDs
8600 (Human); 21943 (Mouse); 117516 (Rat); 102137946 (Cynomolgus Monkey)
Alternate Names
CD254 antigen; CD254; ODF; OPGL; OPGLOPTB2; Osteoclast differentiation factor; Osteoprotegerin ligand; RANK L; RANKL; RANKLreceptor activator of nuclear factor kappa B ligand; Receptor activator of nuclear factor kappa-B ligand; sOdf; TNF-related activation-induced cytokine; TNFSF11; TRANCE; TRANCEODFhRANKL2; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand superfamily member 11

Citations for Recombinant Mouse TRANCE/RANK L/TNFSF11 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

88 Citations: Showing 1 - 10
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  1. IL-17 promotes osteoclast-induced bone loss by regulating glutamine-dependent energy metabolism
    Authors: Peng, R;Dong, Y;Zheng, M;Kang, H;Wang, P;Zhu, M;Song, K;Wu, W;Li, F;
    Cell death & disease
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Geranylgeraniol (GGOH), incorporated into a bone cement pellet promotes osteoclast function and healing in a model of medication-related osteonecrosis of the jaw
    Authors: Feldman, G;Young, D;Freeman, T;Israel, L;Taub, D;Diecidue, R;
    Journal of oral biology and craniofacial research
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Optineurin regulates NRF2-mediated antioxidant response in a mouse model of Paget's disease of bone
    Authors: X Hu, SW Wong, K Liang, TH Wu, S Wang, L Wang, J Liu, M Yamauchi, BL Foster, JP Ting, B Zhao, HC Tseng, CC Ko
    Science Advances, 2023-01-27;9(4):eade6998.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Yoda1 Enhanced Low-Magnitude High-Frequency Vibration on Osteocytes in Regulation of MDA-MB-231 Breast Cancer Cell Migration
    Authors: CY Lin, X Song, Y Ke, A Raha, Y Wu, M Wasi, L Wang, F Geng, L You
    Cancers, 2022-07-13;14(14):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. 7-Ketocholesterol-Induced Micro-RNA-107-5p Increases Number and Activity of Osteoclasts by Targeting MKP1
    Authors: G Li, OJ Sul, R Yu, HS Choi
    International Journal of Molecular Sciences, 2022-03-28;23(7):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  6. Bisphosphonate-enoxacin inhibit osteoclast formation and function by abrogating RANKL-induced JNK signalling pathways during osteoporosis treatment
    Authors: Q Xu, P Zhan, X Li, F Mo, H Xu, Y Liu, Q Lai, B Zhang, M Dai, X Liu
    Journal of Cellular and Molecular Medicine, 2021-10-15;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  7. Bone Marrow Homeostasis Is Impaired via JAK/STAT and Glucocorticoid Signaling in Cancer Cachexia Model
    Authors: J Yu, S Choi, A Park, J Do, D Nam, Y Kim, J Noh, KY Lee, CH Maeng, KS Park
    Cancers, 2021-03-02;13(5):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  8. CCR3 deficiency is associated with increased osteoclast activity and reduced cortical bone volume in adult male mice
    Authors: S Rosendahl, R Sulniute, M Eklund, C Koskinen H, MJO Johansson, E Kindstedt, S Lindquist, P Lundberg
    The Journal of Biological Chemistry, 2020-12-17;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  9. Tetrandrine Inhibits Titanium Particle-Induced Inflammatory Osteolysis through the Nuclear Factor-&kappaB Pathway
    Authors: Z Liu, Y Li, F Guo, C Zhang, G Song, J Yang, D Chen
    Mediators of Inflammation, 2020-11-27;2020(0):1926947.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  10. Puerarin alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via inhibition of TRAF6/ROS-dependent MAPK/NF-&kappaB signaling pathways
    Authors: L Xiao, M Zhong, Y Huang, J Zhu, W Tang, D Li, J Shi, A Lu, H Yang, D Geng, H Li, Z Wang
    Aging (Albany NY), 2020-11-07;12(21):21706-21729.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  11. Inhibitory effects of dabigatran etexilate, a direct thrombin inhibitor, on osteoclasts and osteoblasts
    Authors: AL Rocha, RL Bighetti-T, LF Duffles, JAA de Arruda, TM Taira, BRD Assis, S Macari, IMA Diniz, MM Beloti, AL Rosa, SY Fukada, GAC Goulart, DD Ribeiro, LG Abreu, TA Silva
    Thromb. Res., 2019-12-23;186(0):45-53.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Autophagy promotes osteoclast podosome disassembly and cell motility athrough the interaction of kindlin3 with LC3
    Authors: Y Zhang, Y Cui, L Wang, J Han
    Cell. Signal., 2019-12-17;67(0):109505.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. The protective effect of WKYMVm peptide on inflammatory osteolysis through regulating NF-kappaB and CD9/gp130/STAT3 signalling pathway
    Authors: J Hu, X Li, Y Chen, X Han, L Li, Z Yang, L Duan, H Lu, Q He
    J. Cell. Mol. Med., 2019-12-14;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  14. GIP analogues augment bone strength by modulating bone composition in diet-induced obesity in mice
    Authors: SS Vyavahare, A Mieczkowsk, PR Flatt, D Chappard, N Irwin, G Mabilleau
    Peptides, 2019-11-22;0(0):170207.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  15. Inhibitory effects of ChondroT and its constituent herbs on RANKL-induced osteoclastogenesis
    Authors: RH Guo, SJ Kim, CH Choi, CS Na, BY Kang, YR Kim
    BMC Complement Altern Med, 2019-11-20;19(1):319.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  16. Characterizing how probiotic Lactobacillus reuteri 6475 and lactobacillic acid mediate suppression of osteoclast differentiation
    Authors: D Quach, N Parameswar, L McCabe, RA Britton
    Bone Rep, 2019-11-02;11(0):100227.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Tetrabromobisphenol A Promotes the Osteoclastogenesis of RAW264.7 Cells Induced by Receptor Activator of NF-kappa B Ligand In Vitro
    Authors: SY Park, EM Choi, KS Suh, HS Kim, SO Chin, SY Rhee, DY Kim, S Oh, S Chon
    J. Korean Med. Sci., 2019-10-28;34(41):e267.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  18. MicroRNA-29a Counteracts Glucocorticoid Induction of Bone Loss through Repressing TNFSF13b Modulation of Osteoclastogenesis
    Authors: RW Wu, WS Lian, YS Chen, CW Kuo, HC Ke, CK Hsieh, SY Wang, JY Ko, FS Wang
    Int J Mol Sci, 2019-10-17;20(20):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  19. Phillyrin Attenuates Osteoclast Formation and Function and Prevents LPS-Induced Osteolysis in Mice
    Authors: J Wang, G Chen, Q Zhang, F Zhao, X Yu, X Ma, M Liu
    Front Pharmacol, 2019-10-17;10(0):1188.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Lycorine Attenuates Autophagy in Osteoclasts via an Axis of mROS/TRPML1/TFEB to Reduce LPS-Induced Bone Loss
    Authors: HJ Park, M Gholam-Zad, JH Suh, HS Choi
    Oxid Med Cell Longev, 2019-10-08;2019(0):8982147.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  21. Nobiletin-loaded micelles reduce ovariectomy-induced bone loss by suppressing osteoclastogenesis
    Authors: Y Wang, J Xie, Z Ai, J Su
    Int J Nanomedicine, 2019-09-26;14(0):7839-7849.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  22. Bone loss caused by dopaminergic degeneration and levodopa treatment in Parkinson's disease model mice
    Authors: K Handa, S Kiyohara, T Yamakawa, K Ishikawa, M Hosonuma, N Sakai, A Karakawa, M Chatani, M Tsuji, K Inagaki, Y Kiuchi, M Takami, T Negishi-Ko
    Sci Rep, 2019-09-24;9(1):13768.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  23. The Nrf2 activator RTA-408 attenuates osteoclastogenesis by inhibiting STING dependent NF-?b signaling
    Authors: X Sun, Z Xie, B Hu, B Zhang, Y Ma, X Pan, H Huang, J Wang, X Zhao, Z Jie, P Shi, Z Chen
    Redox Biol, 2019-08-27;28(0):101309.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Stachydrine prevents LPS-induced bone loss by inhibiting osteoclastogenesis via NF-κB and Akt signalling
    Authors: J Meng, C Zhou, W Zhang, W Wang, B He, B Hu, G Jiang, Y Wang, J Hong, S Li, J He, S Yan, W Yan
    J. Cell. Mol. Med., 2019-07-21;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  25. Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis
    Authors: YS Yang, J Xie, D Wang, JM Kim, PWL Tai, E Gravallese, G Gao, JH Shim
    Nat Commun, 2019-07-04;10(1):2958.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  26. Adult stem cell deficits drive Slc29a3 disorders in mice
    Authors: S Nair, AM Strohecker, AK Persaud, B Bissa, S Muruganand, C McElroy, R Pathak, M Williams, R Raj, A Kaddoumi, A Sparreboom, AM Beedle, R Govindaraj
    Nat Commun, 2019-07-03;10(1):2943.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Differentiation, Differentiation
  27. MyD88 and IL-1R signaling drive antibacterial immunity and osteoclast-driven bone loss during Staphylococcus aureus osteomyelitis
    Authors: NE Putnam, LE Fulbright, JM Curry, CA Ford, JR Petronglo, AS Hendrix, JE Cassat
    PLoS Pathog., 2019-04-12;15(4):e1007744.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. PI3K activation increases SDF-1 production and number of osteoclast precursors, and enhances SDF-1-mediated osteoclast precursor migration
    Authors: NS Adapala, S Root, J Lorenzo, H Aguila, A Sanjay
    Bone Rep, 2019-03-22;10(0):100203.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Gold Clusters Prevent Inflammation-Induced Bone Erosion through Inhibiting the Activation of NF-?B Pathway
    Authors: Q Yuan, F Gao, Y Yao, P Cai, X Zhang, J Yuan, K Hou, L Gao, X Ren, X Gao
    Theranostics, 2019-03-01;9(7):1825-1836.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. A potential therapeutic target for regulating osteoporosis via suppression of osteoclast differentiation
    Authors: Q Sun, B Zhang, W Zhu, W Wei, J Ma, FR Tay
    J Dent, 2019-02-01;0(0):.
    Species: Mouse
    Sample Types:
    Applications: Bioassay
  31. Treatment of collagenase-induced osteoarthritis with a viral vector encoding TSG-6 results in ectopic bone formation
    Authors: MGA Broeren, I Di Ceglie, MB Bennink, PLEM van Lent, WB van den Be, MI Koenders, EN Blaney Dav, PM van der Kr, FAJ van de Loo
    PeerJ, 2018-05-30;6(0):e4771.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Fc? receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis
    Authors: I Di Ceglie, G Ascone, NAJ Cremers, AW Sloetjes, B Walgreen, T Vogl, J Roth, JS Verbeek, FAJ van de Loo, MI Koenders, PM van der Kr, AB Blom, MHJ van den Bo, PLEM van Lent
    Arthritis Res. Ther., 2018-05-02;20(1):80.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  33. LncRNA-AK131850 Sponges MiR-93-5p in Newborn and Mature Osteoclasts to Enhance the Secretion of Vascular Endothelial Growth Factor a Promoting Vasculogenesis of Endothelial Progenitor Cells
    Authors: H Quan, M Liang, N Li, C Dou, C Liu, Y Bai, W Luo, J Li, F Kang, Z Cao, X Yang, H Jiang, S Dong
    Cell. Physiol. Biochem., 2018-03-23;46(1):401-417.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Suppression Effect of Astaxanthin on Osteoclast Formation In Vitro and Bone Loss In Vivo
    Authors: YH Hwang, KJ Kim, SJ Kim, SK Mun, SG Hong, YJ Son, ST Yee
    Int J Mol Sci, 2018-03-19;19(3):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice
    Authors: IR Orriss, S Lanham, D Savery, NDE Greene, P Stanier, R Oreffo, AJ Copp, GL Galea
    Sci Rep, 2018-02-20;8(1):3325.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Ca2+-Dependent Regulation of NFATc1 via KCa3.1 in Inflammatory Osteoclastogenesis
    Authors: EM Grössinger, M Kang, L Bouchareyc, R Sarin, DR Haudenschi, LN Borodinsky, IE Adamopoulo
    J. Immunol., 2017-12-15;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Icariin ameliorates dexamethasone?induced bone deterioration in an experimental mouse model via activation of microRNA?186 inhibition of cathepsin K
    Authors: Y Ma, H Yang, J Huang
    Mol Med Rep, 2017-11-15;17(1):1633-1641.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Differences in responses to X-ray exposure between osteoclast and osteoblast cells
    Authors: J Zhang, Z Wang, A Wu, J Nie, H Pei, W Hu, B Wang, P Shang, B Li, G Zhou
    J. Radiat. Res., 2017-11-01;0(0):1-12.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Salt-inducible kinases (SIK) inhibition reduces RANKL-induced osteoclastogenesis
    Authors: MS Lombardi, C Gilliéron, M Berkelaar, C Gabay
    PLoS ONE, 2017-10-03;12(10):e0185426.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Class II and IV HDACs function as inhibitors of osteoclast differentiation
    Authors: NC Blixt, BK Faulkner, K Astleford, R Lelich, J Schering, E Spencer, R Gopalakris, ED Jensen, KC Mansky
    PLoS ONE, 2017-09-27;12(9):e0185441.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. CCL11, a novel mediator of inflammatory bone resorption
    Authors: E Kindstedt, CK Holm, R Sulniute, I Martinez-C, R Lundmark, P Lundberg
    Sci Rep, 2017-07-13;7(1):5334.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB
    Authors: SY Gao, GS Zheng, L Wang, YJ Liang, SE Zhang, XM Lao, K Li, GQ Liao
    PLoS ONE, 2017-06-08;12(6):e0179248.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice
    Authors: G Colaianni, T Mongelli, C Cuscito, P Pignataro, L Lippo, G Spiro, A Notarnicol, I Severi, G Passeri, G Mori, G Brunetti, B Moretti, U Tarantino, SC Colucci, JE Reseland, R Vettor, S Cinti, M Grano
    Sci Rep, 2017-06-06;7(1):2811.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. 25-hydroxycholesterol promotes RANKL-induced osteoclastogenesis through coordinating NFATc1 and Sp1 complex in the transcription of miR-139-5p
    Authors: L Zhang, Y Lv, G Xian, Y Lin
    Biochem. Biophys. Res. Commun, 2017-02-28;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Gastrodin inhibits osteoclastogenesis via down-regulating the NFATc1 signaling pathway and stimulates osseointegration in vitro
    Authors: F Zhou, Y Shen, B Liu, X Chen, L Wan, D Peng
    Biochem. Biophys. Res. Commun, 2017-02-02;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Scaling of titanium implants entrains inflammation-induced osteolysis
    Authors: M Eger, N Sterer, T Liron, D Kohavi, Y Gabet
    Sci Rep, 2017-01-06;7(0):39612.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Theaflavin-3,3'-digallate represses osteoclastogenesis and prevents wear debris-induced osteolysis via suppression of ERK pathway
    Authors: Dechun Geng
    Acta Biomater, 2016-11-09;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Docosahexaenoic acid signaling attenuates the proliferation and differentiation of bone marrow-derived osteoclast precursors and promotes apoptosis in mature osteoclasts
    Authors: Young-Ran Yoon
    Cell. Signal., 2016-11-09;29(0):226-232.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. FTY720 inhibited proinflammatory cytokine release and osteoclastogenesis induced by Aggregatibacter actinomycetemcomitans.
    Authors: Yu H, Herbert B, Valerio M, Yarborough L, Hsu L, Argraves K
    Lipids Health Dis, 2015-07-04;14(0):66.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Porphyromonas gingivalis Stimulates Bone Resorption by Enhancing RANKL (Receptor Activator of NF-kappaB Ligand) through Activation of Toll-like Receptor 2 in Osteoblasts.
    Authors: Kassem A, Henning P, Lundberg P, Souza P, Lindholm C, Lerner U
    J Biol Chem, 2015-06-17;290(33):20147-58.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  51. WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling.
    Authors: Maeda A, Ono M, Holmbeck K, Li L, Kilts T, Kram V, Noonan M, Yoshioka Y, McNerny E, Tantillo M, Kohn D, Lyons K, Robey P, Young M
    J Biol Chem, 2015-04-11;290(22):14004-18.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  52. 5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival.
    Authors: Maruyama K, Fukasaka M, Uematsu S, Takeuchi O, Kondo T, Saitoh T, Martino M, Akira S
    J Biol Chem, 2015-02-17;290(15):9377-86.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  53. A novel phthalimide derivative, TC11, has preclinical effects on high-risk myeloma cells and osteoclasts.
    Authors: Matsushita M, Ozaki Y, Hasegawa Y, Terada F, Tabata N, Shiheido H, Yanagawa H, Oikawa T, Matsuo K, Du W, Yamada T, Hozumi M, Ichikawa D, Hattori Y
    PLoS ONE, 2015-01-24;10(1):e0116135.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Comprehensive profiling analysis of actively resorbing osteoclasts identifies critical signaling pathways regulated by bone substrate.
    Authors: Purdue, P Edward, Crotti, Tania N, Shen, Zhenxin, Swantek, Jennifer, Li, Jun, Hill, Jonathan, Hanidu, Adedayo, Dimock, Janice, Nabozny, Gerald, Goldring, Steven R, McHugh, Kevin P
    Sci Rep, 2014-12-23;4(0):7595.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Modulation of osteoclastogenesis with macrophage M1- and M2-inducing stimuli.
    Authors: Jeganathan S, Fiorino C, Naik U, Sun H, Harrison R
    PLoS ONE, 2014-08-07;9(8):e104498.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  56. SHIP1 regulates MSC numbers and their osteolineage commitment by limiting induction of the PI3K/Akt/beta-catenin/Id2 axis.
    Authors: Iyer S, Viernes D, Chisholm J, Margulies B, Kerr W
    Stem Cells Dev, 2014-07-03;23(19):2336-51.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  57. miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.
    Authors: Krzeszinski J, Wei W, Huynh H, Jin Z, Wang X, Chang T, Xie X, He L, Mangala L, Lopez-Berestein G, Sood A, Mendell J, Wan Y
    Nature, 2014-06-25;512(7515):431-5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  58. DLX3 regulates bone mass by targeting genes supporting osteoblast differentiation and mineral homeostasis in vivo.
    Authors: Isaac, J, Erthal, J, Gordon, J, Duverger, O, Sun, H-W, Lichtler, A C, Stein, G S, Lian, J B, Morasso, M I
    Cell Death Differ, 2014-06-20;21(9):1365-76.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Bisphosphonates inhibit osteosarcoma-mediated osteolysis via attenuation of tumor expression of MCP-1 and RANKL.
    Authors: Ohba T, Cole H, Cates J, Slosky D, Haro H, Ando T, Schwartz H, Schoenecker J
    J Bone Miner Res, 2014-06-01;29(6):1431-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Reactive oxygen species induce the association of SHP-1 with c-Src and the oxidation of both to enhance osteoclast survival.
    Authors: Ke K, Sul O, Choi E, Safdar A, Kim E, Choi H
    Am J Physiol Endocrinol Metab, 2014-05-13;307(1):E61-70.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  61. FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation.
    Authors: Bartell, Shoshana, Kim, Ha-Neui, Ambrogini, Elena, Han, Li, Iyer, Srividhy, Serra Ucer, S, Rabinovitch, Peter, Jilka, Robert L, Weinstein, Robert S, Zhao, Haibo, O'Brien, Charles, Manolagas, Stavros, Almeida, Maria
    Nat Commun, 2014-04-30;5(0):3773.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Effects of the peroxisome proliferator-activated receptor (PPAR)-delta agonist GW501516 on bone and muscle in ovariectomized rats.
    Authors: Mosti M, Stunes A, Ericsson M, Pullisaar H, Reseland J, Shabestari M, Eriksen E, Syversen U
    Endocrinology, 2014-04-07;155(6):2178-89.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts.
    Authors: Sharma, Ramaswam, Callaway, Danielle, Vanegas, Difernan, Bendele, Michelle, Lopez-Cruzan, Marisa, Horn, Diane, Guda, Teja, Fajardo, Roberto, Abboud-Werner, Sherry, Herman, Brian
    PLoS ONE, 2014-04-01;9(4):e93696.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Anti-osteoclastogenic activity of praeruptorin A via inhibition of p38/Akt-c-Fos-NFATc1 signaling and PLCgamma-independent Ca2+ oscillation.
    Authors: Yeon J, Kim K, Choi S, Moon S, Park Y, Ryu B, Oh J, Kim M, Erkhembaatar M, Son Y, Kim S
    PLoS ONE, 2014-02-21;9(2):e88974.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  65. (+)-Vitisin A inhibits osteoclast differentiation by preventing TRAF6 ubiquitination and TRAF6-TAK1 formation to suppress NFATc1 activation.
    Authors: Chiou W, Huang Y, Liu Y
    PLoS ONE, 2014-02-18;9(2):e89159.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  66. OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.
    Authors: Gwyer Findlay, Emily, Danks, Lynett, Madden, Jodie, Cavanagh, Mary M, McNamee, Kay, McCann, Fiona, Snelgrove, Robert J, Shaw, Stevan, Feldmann, Marc, Taylor, Peter Ch, Horwood, Nicole J, Hussell, Tracy
    Proc Natl Acad Sci U S A, 2014-01-27;111(6):2289-94.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  67. The transcription factor T-box 3 regulates colony-stimulating factor 1-dependent Jun dimerization protein 2 expression and plays an important role in osteoclastogenesis.
    Authors: Yao C, Yao G, Sun B, Zhang C, Tommasini S, Insogna K
    J Biol Chem, 2014-01-06;289(10):6775-90.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  68. An inducible, ligand-independent receptor activator of NF-kappaB gene to control osteoclast differentiation from monocytic precursors.
    Authors: Rementer C, Wu M, Buranaphatthana W, Yang H, Scatena M, Giachelli C
    PLoS ONE, 2013-12-27;8(12):e84465.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Microtubule dynamic instability controls podosome patterning in osteoclasts through EB1, cortactin, and Src.
    Authors: Biosse Duplan, Martin, Zalli, Detina, Stephens, Sebastie, Zenger, Serhan, Neff, Lynn, Oelkers, J Margit, Lai, Frank P, Horne, William, Rottner, Klemens, Baron, Roland
    Mol Cell Biol, 2013-10-21;34(1):16-29.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Interleukin-33 and alveolar macrophages contribute to the mechanisms underlying the exacerbation of IgE-mediated airway inflammation and remodelling in mice.
    Authors: Mizutani N, Nabe T, Yoshino S
    Immunology, 2013-06-01;139(2):205-18.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Liver X receptor activation inhibits osteoclastogenesis by suppressing NF-kappaB activity and c-Fos induction and prevents inflammatory bone loss in mice.
    Authors: Kim H, Yoon K, Yoon H, Hong J, Lee M, Lee I, Kim S
    J Leukoc Biol, 2013-05-08;94(1):99-107.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Mitogen-activated protein kinase 2 regulates physiological and pathological bone turnover.
    Authors: Braun T, Lepper J, Ruiz Heiland G, Hofstetter W, Siegrist M, Lezuo P, Gaestel M, Rumpler M, Thaler R, Klaushofer K, Distler J, Schett G, Zwerina J
    J Bone Miner Res, 2013-04-01;28(4):936-47.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  73. RNA interference-mediated silencing of Atp6i prevents both periapical bone erosion and inflammation in the mouse model of endodontic disease.
    Authors: Ma, Junqing, Chen, Wei, Zhang, Lijie, Tucker, Byron, Zhu, Guochun, Sasaki, Hajime, Hao, Liang, Wang, Lin, Ci, Honglian, Jiang, Hongbing, Stashenko, Philip, Li, Yi-Ping
    Infect Immun, 2013-04-01;81(4):1021-30.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Silent information regulator (Sir)T1 inhibits NF-kappaB signaling to maintain normal skeletal remodeling.
    Authors: Edwards J, Perrien D, Fleming N, Nyman J, Ono K, Connelly L, Moore M, Lwin S, Yull F, Mundy G, Elefteriou F
    J Bone Miner Res, 2013-04-01;28(4):960-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Nicotine affects bone resorption and suppresses the expression of cathepsin K, MMP-9 and vacuolar-type H(+)-ATPase d2 and actin organization in osteoclasts.
    Authors: Tanaka H, Tanabe N, Kawato T, Nakai K, Kariya T, Matsumoto S, Zhao N, Motohashi M, Maeno M
    PLoS ONE, 2013-03-15;8(3):e59402.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Porphyromonas gingivalis infection-associated periodontal bone resorption is dependent on receptor activator of NF-kappaB ligand.
    Authors: Han X, Lin X, Yu X, Lin J, Kawai T, LaRosa K, Taubman M
    Infect Immun, 2013-02-25;81(5):1502-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Overexpression of developmentally regulated GTP-binding protein-2 increases bone loss.
    Authors: Ke K, Sul O, Kim W, Lee M, Ko M, Suh J, Kim H, Kim S, Park J, Choi H
    Am J Physiol Endocrinol Metab, 2013-01-29;304(7):E703-10.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function.
    Authors: Charles, Julia F, Hsu, Lih-Yun, Niemi, Erene C, Weiss, Arthur, Aliprantis, Antonios, Nakamura, Mary C
    J Clin Invest, 2012-11-01;122(12):4592-605.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Osteoclast inhibitory peptide-1 binding to the Fc gammaRIIB inhibits osteoclast differentiation.
    Authors: Shanmugarajan S, Beeson CC, Reddy SV
    Endocrinology, 2010-07-07;151(9):4389-99.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  81. Transient overexpression of sonic hedgehog alters the architecture and mechanical properties of trabecular bone.
    Authors: Kiuru M, Solomon J, Ghali B, van der Meulen M, Crystal RG, Hidaka C
    J. Bone Miner. Res., 2009-09-01;24(9):1598-607.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  82. TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant.
    Authors: Kayamuro H, Yoshioka Y, Abe Y, Katayama K, Yoshida T, Yamashita K, Yoshikawa T, Hiroi T, Itoh N, Kawai Y, Mayumi T, Kamada H, Tsunoda S, Tsutsumi Y
    Biochem. Biophys. Res. Commun., 2009-05-04;384(3):296-300.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  83. Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro.
    Authors: Wang L, Zhao R, Shi X, Wei T, Halloran BP, Clark DJ, Jacobs CR, Kingery WS
    Bone, 2009-04-18;45(2):309-20.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  84. Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis.
    Authors: Irie N, Takada Y, Watanabe Y, Matsuzaki Y, Naruse C, Asano M, Iwakura Y, Suda T, Matsuo K
    J. Biol. Chem., 2009-03-19;284(21):14637-44.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  85. Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling.
    Authors: Walker EC, McGregor NE, Poulton IJ, Pompolo S, Allan EH, Quinn JM, Gillespie MT, Martin TJ, Sims NA
    J. Bone Miner. Res., 2008-12-01;23(12):2025-32.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Osteoprotegerin reduces the serum level of receptor activator of NF-kappaB ligand derived from osteoblasts.
    Authors: Nakamichi Y, Udagawa N, Kobayashi Y, Nakamura M, Yamamoto Y, Yamashita T, Mizoguchi T, Sato M, Mogi M, Penninger JM, Takahashi N
    J. Immunol., 2007-01-01;178(1):192-200.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Glucocorticoids act directly on osteoclasts to increase their life span and reduce bone density.
    Authors: Jia D, O'Brien CA, Stewart SA, Manolagas SC, Weinstein RS
    Endocrinology, 2006-08-24;147(12):5592-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  88. IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance.
    Authors: Lubberts E, van den Bersselaar L, Oppers-Walgreen B, Schwarzenberger P, Coenen-de Roo CJ, Kolls JK, Joosten LA, van den Berg WB
    J. Immunol., 2003-03-01;170(5):2655-62.
    Applications: ELISA (Standard)

FAQs

  1. This protein datasheet indicates I need to use a cross-linking antibody, Catalog # MAB050, for biological activity. What is this antibody and is it really necessary?

    • The antibody is directed against a 6x histidine repeat and is recommended for use as a cross-linker of proteins with 6x his-tag. Crosslinking is often used for proteins that require receptor trimerization and can result greater biological activity. R&D Systems Quality Control tests the performance of these proteins in the presence of the cross-linking antibody. Therefore, it is necessary to use this antibody when trying to achieve the same level of specific activity described in the datasheet.

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