Recombinant Mouse Wnt-3a Protein Summary
Product Specifications
Protein concentrations should be titrated based on cell type and if appropriate, passage number of the cell line.
Optimal concentrations should be determined by each laboratory for each application.
Ser19-Lys352
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
1324-WN
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and CHAPS with BSA as a carrier protein. |
Reconstitution | Reconstitute at 40 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
1324-WN/CF
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and CHAPS. |
Reconstitution | Reconstitute at 40 µg/mL in sterile PBS. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Scientific Data
Recombinant Mouse Wnt-3a (Catalog # 1324-WN) induces alkaline phosphatase production by the MC3T3-E1 mouse preosteoblast cell line. The activity is approximately 10-fold greater than the top competitor's Wnt-3A.
Reconstitution Calculator
Background: Wnt-3a
Wnt-3a is one of 19 vertebrate members of the Wingless-type MMTV integration site (Wnt) family of highly conserved cysteine-rich secreted glycoproteins important for normal developmental processes (1). Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta -catenin levels (2). As intracellular beta -catenin levels rise, beta -catenin binds to TCF/LEF transcription factors leading to expression of Wnt target genes (3). Endo-IWR 1 (Catalog # 3532, # PSM1324) is a cell-permeant small molecule inhibitor of Axin turnover that suppresses Wnt signal transduction by stabilizing the beta -catenin destruction complex (4). Wnt-3a is a 44 kDa secreted hydrophobic glycoprotein containing a conserved pattern of 24 cysteine residues (5). Wnt-3a has two N-linked glycosylation sites (Asn 87, Asn 298), and Ser 209 is modified with palmitoleic acid (6). Glycosylation and acylation are essential for efficient Wnt secretion and biological activity, respectively (6, 7). Mouse Wnt-3a shares 96% amino acid (aa) identity with human Wnt-3a, and 97% with bovine and canine Wnt-3a. The rat Wnt-3a precursor shares 100% aa identity with mouse Wnt-3a aa 63-352 (8), and also shares 87% aa identity with Wnt3. During embryonic development, Wnt-3a is necessary for proper development of the hippocampus, anterior-posterior patterning, somite development, and tailbud formation (9-12). Wnt-3a also promotes self-renewal of hematopoietic stem cells, neural stem cells, and embryonic stem cells (13-15).
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- Entrez Accession # NP_001100475.
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- Ten Berge, D. et al. (2011) Nat. Cell Biol. 13:1070.
Citations for Recombinant Mouse Wnt-3a Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Integrin signaling in pluripotent cells acts as a gatekeeper of mouse germline entry
Authors: Makhlouf, A;Wang, A;Sato, N;Rosa, VS;Shahbazi, MN;
Science advances
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Neuro-mesenchymal interaction mediated by a ?2 adrenergic-nerve growth factor feedforward loop promotes colorectal cancer progression
Authors: Kobayashi, H;Iida, T;Ochiai, Y;Malagola, E;Zhi, X;White, RA;Qian, J;Wu, F;Waterbury, QT;Tu, R;Zheng, B;LaBella, JS;Zamechek, LB;Ogura, A;Woods, SL;Worthley, DL;Enomoto, A;Wang, TC;
Cancer discovery
Species: Mouse
Sample Types: Organoid
Applications: Bioassay -
GSK3? Inhibitors Inhibit TGF? Signaling in the Human Trabecular Meshwork
Authors: Sugali, CK;Rayana, NP;Dai, J;Harvey, DH;Dhamodaran, K;Mao, W;
Investigative ophthalmology & visual science
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Enhanced chondrogenic potential in GelMA-based 3D cartilage model via Wnt3a surface immobilization
Authors: Imere, A;Foster, NC;Hajiali, H;Okur, KE;Wright, AL;Barroso, IA;Haj, AJE;
Scientific reports
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota
Authors: Greiner, TU;Koh, A;Peris, E;Bergentall, M;Johansson, MEV;Hansson, GC;Drucker, DJ;Bäckhed, F;
Molecular metabolism
Species: Mouse
Sample Types: Organoid
Applications: Bioassay -
5-Aza-2'-Deoxycytidine Ameliorates Choroidal Neovascularization by Inhibiting the Wnt/?-Catenin Signaling Pathway
Authors: Wu, X;Yang, X;Dai, X;Chen, X;Shen, M;Dai, J;Yuan, F;Wang, L;Yuan, Y;Feng, Y;
Investigative ophthalmology & visual science
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression
Authors: Hasselluhn, MC;Decker-Farrell, AR;Vlahos, L;Thomas, DH;Curiel-Garcia, A;Maurer, HC;Wasko, UN;Tomassoni, L;Sastra, SA;Palermo, CF;Dalton, TC;Ma, A;Li, F;Tolosa, EJ;Hibshoosh, H;Fernandez-Zapico, ME;Muir, A;Califano, A;Olive, KP;
Cancer discovery
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
Single-cell RNA sequencing of intestinal crypts reveals vital events in damage repair and the double-edged sword effect of the Wnt3/?-catenin pathway in irradiated mice
Authors: Yuan, T;Zhang, J;Zhao, Y;Guo, Y;Fan, S;
Redox biology
Species: Mouse
Sample Types: Organoids
Applications: Bioassay -
Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration
Authors: Sun, L;Zhang, X;Wu, S;Liu, Y;Guerrero-Juarez, CF;Liu, W;Huang, J;Yao, Q;Yin, M;Li, J;Ramos, R;Liao, Y;Wu, R;Xia, T;Zhang, X;Yang, Y;Li, F;Heng, S;Zhang, W;Yang, M;Tzeng, CM;Ji, C;Plikus, MV;Gallo, RL;Zhang, LJ;
Cell reports
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme
Authors: Alber, AB;Marquez, HA;Ma, L;Kwong, G;Thapa, BR;Villacorta-Martin, C;Lindstrom-Vautrin, J;Bawa, P;Wang, F;Luo, Y;Ikonomou, L;Shi, W;Kotton, DN;
Nature communications
Species: Transgenic Mouse
Sample Types: Organoid
Applications: Bioassay -
Elevated FOXG1 in glioblastoma stem cells cooperates with Wnt/?-catenin to induce exit from quiescence
Authors: Robertson, FL;O'Duibhir, E;Gangoso, E;Bressan, RB;Bulstrode, H;Marqu�s-Torrej�n, M�;Ferguson, KM;Blin, C;Grant, V;Alfazema, N;Morrison, GM;Pollard, SM;
Cell reports
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Characterization of Inflammatory Signals in BV-2 Microglia in Response to Wnt3a
Authors: Li, C;Wu, Y;Huang, MY;Song, XJ;
Biomedicines
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Hypercapnia alters stromal-derived Wnt production limiting beta-catenin signaling and proliferation in alveolar type 2 cells
Authors: LA Dada, LC Welch, ND Magnani, Z Ren, H Han, PL Brazee, D Celli, AS Flozak, A Weng, MM Herrerias, V Kryvenko, I Vadász, CE Runyan, H Abdala-Val, M Shigemura, SM Casalino-M, AV Misharin, GRS Budinger, CJ Gottardi, JI Sznajder
JCI Insight, 2023-02-22;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Simple Detection and Culture of Circulating Tumor Cells from Colorectal Cancer Patients Using Poly(2-Methoxyethyl Acrylate)-Coated Plates
Authors: M Nomura, Y Yokoyama, D Yoshimura, Y Minagawa, A Yamamoto, Y Tanaka, N Sekiguchi, D Marukawa, M Ichihara, H Itakura, K Matsumoto, Y Morimoto, H Tomihara, A Inoue, T Ogino, N Miyoshi, H Takahashi, H Takahashi, M Uemura, S Kobayashi, T Mizushima, T Anada, M Mori, Y Doki, M Tanaka, H Eguchi, H Yamamoto
International Journal of Molecular Sciences, 2023-02-16;24(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Expansion of ventral foregut is linked to changes in the enhancer landscape for organ-specific differentiation
Authors: YF Wong, Y Kumar, M Proks, JAR Herrera, MM Rothová, RS Monteiro, S Pozzi, RE Jennings, NA Hanley, WA Bickmore, JM Brickman
Nature Cell Biology, 2023-01-23;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select
Authors: Y Niu, CA Ferreira A, X Li, E Kamali, O Haagen Nie, C Storgaard, M Frödin
Nature Genetics, 2022-12-05;54(12):1983-1993.
Species: Human
Sample Types: Organoids
Applications: Bioassay -
Cellular shape reinforces niche to stem cell signaling in the small intestine
Authors: N Pentinmikk, R Lozano, S Scharaw, S Andersson, JI Englund, D Castillo-A, A Gallagher, M Broberg, KY Song, A Sola Carva, AT Speidel, M Sundstrom, N Allbritton, MM Stevens, OD Klein, A Teixeira, P Katajisto
Science Advances, 2022-10-14;8(41):eabm1847.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The oncogenic transcription factor FOXQ1 is a differential regulator of Wnt target genes
Authors: G Pizzolato, L Moparthi, S Söderholm, C Cantù, S Koch
Journal of Cell Science, 2022-10-10;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Antibody targeting of E3 ubiquitin ligases for receptor degradation
Authors: H Marei, WK Tsai, YS Kee, K Ruiz, J He, C Cox, T Sun, S Penikalapa, P Dwivedi, M Choi, D Kan, P Saenz-Lope, K Dorighi, P Zhang, YT Kschonsak, N Kljavin, D Amin, I Kim, AG Mancini, T Nguyen, C Wang, E Janezic, A Doan, E Mai, H Xi, C Gu, M Heinlein, B Biehs, J Wu, I Lehoux, S Harris, L Comps-Agra, D Seshasayee, FJ de Sauvage, M Grimmer, J Li, NJ Agard, F de Sousa E
Nature, 2022-09-21;610(7930):182-189.
Species: Human
Sample Types: Transfected Whole Cells
Applications: Bioassay -
Dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm
Authors: Z Wang, R Fan, A Russo, FM Cernilogar, A Nuber, S Schirge, I Shcherbako, I Dzhilyanov, E Ugur, T Anton, L Richter, H Leonhardt, H Lickert, G Schotta
Nature Communications, 2022-09-19;13(1):5447.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
R-spondin3 is a myokine that differentiates myoblasts to type I fibres
Authors: Y Mita, H Zhu, Y Furuichi, H Hamaguchi, Y Manabe, NL Fujii
Scientific Reports, 2022-07-29;12(1):13020.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Functionalized 3D-Printed ST2/Gelatin Methacryloyl/Polcaprolactone Scaffolds for Enhancing Bone Regeneration with Vascularization
Authors: G Liu, J Chen, X Wang, Y Liu, Y Ma, X Tu
International Journal of Molecular Sciences, 2022-07-28;23(15):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme
Authors: G Jacquemin, A Wurmser, M Huyghe, W Sun, Z Homayed, C Merle, M Perkins, F Qasrawi, S Richon, F Dingli, G Arras, D Loew, D Vignjevic, J Pannequin, S Fre
Elife, 2022-05-11;11(0):.
Species: Mouse
Sample Types: Organoids
Applications: Bioassay -
Follistatin-like 1 (FSTL1) interacts with Wnt ligands and Frizzled receptors to enhance Wnt/beta-catenin signaling in obstructed kidneys in vivo
Authors: Y Zhang, Y Wang, G Zheng, Y Liu, J Li, H Huang, C Xu, Y Zeng, X Zhang, J Qin, C Dai, HO Hambrock, U Hartmann, B Feng, KK Mak, Y Liu, HY Lan, Y Huang, ZH Zheng, Y Xia
The Journal of Biological Chemistry, 2022-05-04;0(0):102010.
Species: Mouse
Sample Types: Whole Cell
Applications: Cell Culture -
The Tumor Microenvironment Drives Intrahepatic Cholangiocarcinoma Progression
Authors: S Mancarella, G Serino, S Coletta, R Armentano, F Dituri, F Ardito, A Ruzzenente, I Fabregat, G Giannelli
International Journal of Molecular Sciences, 2022-04-10;23(8):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Platelet-derived growth factor-BB regenerates functional periodontal ligament in the tooth replantation
Authors: K Komatsu, H Ideno, T Shibata, K Nakashima, A Nifuji
Scientific Reports, 2022-02-25;12(1):3223.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Transplantation of intestinal organoids into a mouse model of colitis
Authors: S Watanabe, S Kobayashi, N Ogasawara, R Okamoto, T Nakamura, M Watanabe, KB Jensen, S Yui
Nature Protocols, 2022-02-02;0(0):.
Species: Mouse
Sample Types: Organoids
Applications: Bioassay -
Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution
Authors: CM Termini, A Pang, T Fang, M Roos, VY Chang, Y Zhang, NJ Setiawan, L Signaevska, M Li, MM Kim, O Tabibi, PK Lin, JP Sasine, A Chatterjee, R Murali, HA Himburg, JP Chute
Nature Communications, 2021-11-30;12(1):6990.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas
Authors: S Heino, S Fang, M Lähde, J Högström, S Nassiri, A Campbell, D Flanagan, A Raven, M Hodder, N Nasreddin, HH Xue, M Delorenzi, S Leedham, TV Petrova, O Sansom, K Alitalo
Science Advances, 2021-11-17;7(47):eabj0512.
Species: Mouse
Sample Types: Organoids
Applications: Bioassay -
Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors
Authors: RJ Geusz, A Wang, DK Lam, NK Vinckier, KD Alysandrat, DA Roberts, J Wang, S Kefalopoul, A Ramirez, Y Qiu, J Chiou, KJ Gaulton, B Ren, DN Kotton, M Sander
Nature Communications, 2021-11-17;12(1):6636.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling
Authors: C Shen, A Nayak, LR Neitzel, AA Adams, M Silver-Ise, LM Sawyer, H Benchabane, H Wang, N Bunnag, B Li, DT Wynn, F Yang, M Garcia-Con, CH Williams, S Dakshanamu, CC Hong, NG Ayad, AJ Capobianco, Y Ahmed, E Lee, DJ Robbins
Nature Communications, 2021-09-06;12(1):5263.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells
Authors: N Aaron, MJ Kraakman, Q Zhou, Q Liu, S Costa, J Yang, L Liu, L Yu, L Wang, Y He, L Fan, H Hirakawa, L Ding, J Lo, W Wang, B Zhao, E Guo, L Sun, CJ Rosen, L Qiang
Elife, 2021-06-22;10(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Wnt signaling enhances macrophage responses to IL-4 and promotes resolution of atherosclerosis
Authors: A Weinstock, K Rahman, O Yaacov, H Nishi, P Menon, CA Nikain, ML Garabedian, S Pena, N Akbar, BE Sansbury, SP Heffron, J Liu, G Marecki, D Fernandez, EJ Brown, KV Ruggles, SA Ramsey, C Giannarell, M Spite, RP Choudhury, P Loke, EA Fisher
Elife, 2021-03-15;10(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Phosphorylation-induced changes in the PDZ domain of Dishevelled 3
Authors: M Jurásek, J Kumar, P Paclíková, A Kumari, K Tripsianes, V Bryja, R Vácha
Scientific Reports, 2021-01-15;11(1):1484.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
12-O-Tetradecanoylphorbol-13-acetate increases cardiomyogenesis through PKC/ERK signaling
Authors: KA Radaszkiew, D Beckerová, L Woloszczuk, TW Radaszkiew, P Lesáková, OV Blaná?ová, L Kubala, P Humpolí?ek, J Pachernik
Sci Rep, 2020-09-28;10(1):15922.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Wnt/&beta-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells
Authors: DP Bagchi, A Nishii, Z Li, JB DelPropost, CA Corsa, H Mori, J Hardij, BS Learman, CN Lumeng, OA MacDougald
Mol Metab, 2020-09-09;42(0):101078.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Drug-Induced Na�ve iPS Cells Exhibit Better Performance than Primed iPS Cells with Respect to the Ability to Differentiate into Pancreatic &beta-Cell Lineage
Authors: Y Kiyokawa, M Sato, H Noguchi, E Inada, Y Iwase, N Kubota, T Sawami, M Terunuma, T Maeda, H Hayasaki, I Saitoh
Journal of Clinical Medicine, 2020-09-02;9(9):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In�Vivo
Authors: Y Miao, A Ha, W de Lau, K Yuki, AJM Santos, C You, MH Geurts, J Puschhof, C Pleguezuel, WC Peng, R Senlice, C Piani, JW Buikema, OM Gbenedio, M Vallon, J Yuan, S de Haan, W Hemrika, K Rösch, LT Dang, D Baker, M Ott, P Depeille, SM Wu, J Drost, R Nusse, JP Roose, J Piehler, SF Boj, CY Janda, H Clevers, CJ Kuo, KC Garcia
Cell Stem Cell, 2020-08-19;0(0):.
Species: Mouse
Sample Types: Organoids, Whole Cells
Applications: Bioassay -
Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State
Authors: L Zhang, J Avery, A Yin, AM Singh, TS Cliff, H Yin, S Dalton
Cell Stem Cell, 2020-08-11;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Differential Histone Distribution Patterns in Induced Asymmetrically Dividing Mouse Embryonic Stem Cells
Authors: B Ma, TJ Trieu, J Cheng, S Zhou, Q Tang, J Xie, JL Liu, K Zhao, SJ Habib, X Chen
Cell Rep, 2020-08-11;32(6):108003.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Ryk modulates the niche activity of mesenchymal stromal cells by fine-tuning canonical Wnt signaling
Authors: SY Jeong, J Lyu, JA Kim, IH Oh
Exp. Mol. Med., 2020-07-28;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development
Authors: NK Vinckier, NA Patel, RJ Geusz, A Wang, J Wang, I Matta, AR Harrington, M Wortham, N Wetton, J Wang, US Jhala, MG Rosenfeld, CW Benner, HP Shih, M Sander
Nat Commun, 2020-04-29;11(1):2082.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction
Authors: DP Bagchi, Z Li, CA Corsa, J Hardij, H Mori, BS Learman, KT Lewis, RL Schill, SM Romanelli, OA MacDougald
Mol Metab, 2020-04-20;0(0):100992.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Low-dose interleukin-2 alleviates dextran sodium sulfate-induced colitis in mice by recovering intestinal integrity and inhibiting AKT-dependent pathways
Authors: H Lee, YS Son, MO Lee, JW Ryu, K Park, O Kwon, KB Jung, K Kim, TY Ryu, A Baek, J Kim, CR Jung, CM Ryu, YJ Park, TS Han, DS Kim, HS Cho, MY Son
Theranostics, 2020-04-06;10(11):5048-5063.
Species: Mouse
Sample Types: Colon
Applications: Cell Culture -
Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing
Authors: D Gay, G Ghinatti, CF Guerrero-J, RA Ferrer, F Ferri, CH Lim, S Murakami, N Gault, V Barroca, I Rombeau, P Mauffrey, L Irbah, E Treffeisen, S Franz, A Boissonnas, C Combadière, M Ito, MV Plikus, PH Romeo
Sci Adv, 2020-03-20;6(12):eaay3704.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Involvement of Wnt7a in the role of M2c microglia in neural stem cell oligodendrogenesis
Authors: M Mecha, N Yanguas-Ca, A Feliú, L Mestre, FJ Carrillo-S, K Riecken, D Gomez-Nico, C Guaza
J Neuroinflammation, 2020-03-19;17(1):88.
Species: Rat
Sample Types:
Applications: Cell Culture -
Wnt signaling modulator DKK1 as an immunotherapeutic target in ovarian cancer
Authors: I Betella, WJ Turbitt, T Szul, B Wu, A Martinez, A Katre, JA Wall, L Norian, MJ Birrer, R Arend
Gynecol. Oncol., 2020-03-16;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Engraftment potential of maternal adipose-derived stem cells for fetal transplantation
Authors: A Kawashima, R Yasuhara, R Akino, K Mishima, M Nasu, A Sekizawa
Heliyon, 2020-03-04;6(3):e03409.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice
Authors: Y Wada, A Kikuchi, A Kaga, N Shimizu, J Ito, R Onuma, F Fujishima, E Totsune, R Sato, T Niihori, M Shirota, R Funayama, K Sato, T Nakazawa, K Nakayama, Y Aoki, S Aiba, K Nakagawa, S Kure
PLoS Genet., 2020-02-26;16(2):e1008628.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis
Authors: CJ Aros, MK Paul, CJ Pantoja, B Bisht, LK Meneses, P Vijayaraj, JM Sandlin, B France, JA Tse, MW Chen, DW Shia, TM Rickabaugh, R Damoiseaux, BN Gomperts
Cell Rep, 2020-02-18;30(7):2055-2064.e5.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells
Authors: W Liang, P Han, EH Kim, J Mak, R Zhang, AG Torrente, JI Goldhaber, E Marbán, HC Cho
Stem Cells, 2019-12-30;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Ectonucleotide pyrophosphatase 2 (ENPP2) plays a crucial role in myogenic differentiation through the regulation by WNT/beta-Catenin signaling
Authors: JP Sah, NTT Hao, X Han, TTT Tran, S McCarthy, Y Oh, JK Yoon
Int. J. Biochem. Cell Biol., 2019-12-02;118(0):105661.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Sonic hedgehog connects podocyte injury to mesangial activation and glomerulosclerosis
Authors: D Zhou, H Fu, Y Han, L Zhang, S Liu, L Lin, DB Stolz, Y Liu
JCI Insight, 2019-11-14;4(22):.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay -
The transcription factor NKX1-2 promotes adipogenesis and may contribute to a balance between adipocyte and osteoblast differentiation
Authors: N Chen, RL Schill, M O'Donnell, K Xu, DP Bagchi, OA MacDougald, RJ Koenig, B Xu
J. Biol. Chem., 2019-10-15;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Bioassay -
Pre-marked chromatin and transcription factor co-binding shape the pioneering activity of Foxa2
Authors: FM Cernilogar, S Hasenöder, Z Wang, K Scheibner, I Burtscher, M Sterr, P Smialowski, S Groh, IM Evenroed, GD Gilfillan, H Lickert, G Schotta
Nucleic Acids Res., 2019-09-26;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
NOD2 Supports Crypt Survival and Epithelial Regeneration after Radiation-Induced Injury
Authors: C Lee, C Choi, HS Kang, SW Shin, SY Kim, HC Park, SN Hong
Int J Mol Sci, 2019-09-02;20(17):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Identification of a pro-angiogenic functional role for FSP1-positive fibroblast subtype in wound healing
Authors: S Saraswati, SMW Marrow, LA Watch, PP Young
Nat Commun, 2019-07-09;10(1):3027.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
KRAS activation in gastric adenocarcinoma stimulates epithelial-to-mesenchymal transition to cancer stem-like cells and promotes metastasis
Authors: C Yoon, J Till, SJ Cho, KK Chang, JX Lin, CM Huang, S Ryeom, SS Yoon
Mol. Cancer Res., 2019-06-19;0(0):.
Species: Transgenic Mouse
Sample Types: Organoid
Applications: Bioassay -
L-WRN conditioned medium for gastrointestinal epithelial stem cell culture shows replicable batch-to-batch activity levels across multiple research teams
Authors: KL VanDussen, NM Sonnek, TS Stappenbec
Stem Cell Res, 2019-03-27;37(0):101430.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Gfi1b regulates the level of Wnt/?-catenin signaling in hematopoietic stem cells and megakaryocytes
Authors: P Shooshtari, A Helness, C Vadnais, N Brouwer, H Beauchemin, R Chen, H Bagci, FJT Staal, JF Coté, T Möröy
Nat Commun, 2019-03-20;10(1):1270.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells
Authors: M Chapellier, P Peña-Martí, R Ramakrishn, M Eriksson, M Safaee-Tal, C Orsmark-Pi, H Lilljebjör, C Högberg, A Hagström-A, T Fioretos, J Larsson, M Järås
Haematologica, 2019-02-28;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects
Authors: J Ooi, SR Langley, X Xu, KH Utami, B Sim, Y Huang, NP Harmston, YL Tay, A Ziaei, R Zeng, D Low, F Aminkeng, RM Sobota, F Ginhoux, E Petretto, MA Pouladi
Cell Rep, 2019-02-26;26(9):2494-2508.e7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Reduced production of laminin by hepatic stellate cells contributes to impairment in oval cell response to liver injury in aged mice
Authors: L Qian, H Zhang, Y Gu, D Li, S He, H Wang, Y Cheng, W Yang, H Yu, X Zhao, W Cai, L Meng, M Jin, Y Wang, Y Zhang
Aging (Albany NY), 2018-12-04;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Exosomal Wnt-induced dedifferentiation of colorectal cancer cells contributes to chemotherapy resistance
Authors: YB Hu, C Yan, L Mu, YL Mi, H Zhao, H Hu, XL Li, DD Tao, YQ Wu, JP Gong, JC Qin
Oncogene, 2018-11-02;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Integrin-Rac signalling for mammary epithelial stem cell self-renewal
Authors: S Olabi, A Ucar, K Brennan, CH Streuli
Breast Cancer Res., 2018-10-22;20(1):128.
Species: Mouse
Sample Types: Organoids
Applications: Bioassay -
WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids
Authors: A Yoney, F Etoc, A Ruzo, T Carroll, JJ Metzger, I Martyn, S Li, C Kirst, ED Siggia, AH Brivanlou
Elife, 2018-10-12;7(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Long-term organoid culture reveals enrichment of organoid-forming epithelial cells in the fimbrial portion of mouse fallopian tube
Authors: Y Xie, ES Park, D Xiang, Z Li
Stem Cell Res, 2018-08-25;32(0):51-60.
Species: Mouse
Sample Types: Organoids
Applications: Bioassay -
Precardiac organoids form two heart fields via Bmp/Wnt signaling
Authors: P Andersen, E Tampakakis, DV Jimenez, S Kannan, M Miyamoto, HK Shin, A Saberi, S Murphy, E Sulistio, SP Chelko, C Kwon
Nat Commun, 2018-08-07;9(1):3140.
Species: Mouse
Sample Types:
-
Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells
Authors: E López-Arri, V Rodilla, C Colomer, A Vert, A Shelton, JH Cheng, B Yan, A Gonzalez-P, MR Junttila, M Iglesias, F Torres, J Albanell, A Villanueva, A Bigas, CW Siebel, L Espinosa
Nat Commun, 2018-07-31;9(1):2992.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
A single cell transcriptional portrait of embryoid body differentiation and comparison to progenitors of the developing embryo
Authors: A Spangler, EY Su, AM Craft, P Cahan
Stem Cell Res, 2018-07-29;31(0):201-215.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Klotho expression is a prerequisite for proper muscle stem cell function and regeneration of skeletal muscle
Authors: HE Ahrens, J Huettemeis, M Schmidt, C Kaether, J von Maltza
Skelet Muscle, 2018-07-04;8(1):20.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine
Authors: Y Muta, Y Fujita, K Sumiyama, A Sakurai, MM Taketo, T Chiba, H Seno, K Aoki, M Matsuda, M Imajo
Nat Commun, 2018-06-05;9(1):2174.
Species: Mouse
Sample Types: Whole Tissue
-
WAIF1 is a cell-surface CTHRC1 binding protein coupling bone resorption and formation
Authors: K Matsuoka, Y Kohara, Y Naoe, A Watanabe, M Ito, K Ikeda, S Takeshita
J. Bone Miner. Res., 2018-05-11;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Wnt signaling activates TIGAR and protects against cisplatin-induced spiral ganglion neuron damage in the mouse cochlea
Authors: W Liu, X Xu, Z Fan, G Sun, Y Han, D Zhang, L Xu, M Wang, X Wang, S Zhang, M Tang, J Li, R Chai, H Wang
Antioxid. Redox Signal., 2018-05-04;0(0):.
Species: Mouse
Sample Types: Tissue Explant
Applications: Bioassay -
Wnt3a ligand facilitates autophagy in hippocampal neurons by modulating a novel GSK-3β-AMPK axis
Authors: JA Ríos, JA Godoy, NC Inestrosa
Cell Commun. Signal, 2018-04-11;16(1):15.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay -
Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC
Authors: J Li, X Wu, Y Zhou, M Lee, L Guo, W Han, W Mo, WM Cao, D Sun, R Xie, Y Huang
Nucleic Acids Res., 2018-04-06;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Targeting ?-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage
Authors: A Held, A Glas, L Dietrich, M Bollmann, K Brandstädt, TN Grossmann, CH Lohmann, T Pap, J Bertrand
Osteoarthr. Cartil., 2018-03-17;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Paracrine Wnt5a-?-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization
Authors: F Zhao, C Xiao, KS Evans, T Theivanthi, N DeVito, A Holtzhause, J Liu, X Liu, D Boczkowski, S Nair, JW Locasale, BA Hanks
Immunity, 2018-01-16;48(1):147-160.e7.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Establishment and characterization of five immortalized human scalp dermal papilla cell lines
Authors: MH Kwack, JM Yang, GH Won, MK Kim, JC Kim, YK Sung
Biochem. Biophys. Res. Commun., 2018-01-10;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial�Changes
Authors: Y Kasagi, PM Chandramou, KA Whelan, K Tanaka, V Giroux, M Sharma, J Wang, AJ Benitez, M DeMarshall, JW Tobias, KE Hamilton, GW Falk, JM Spergel, AJ Klein-Szan, AK Rustgi, AB Muir, H Nakagawa
Cell Mol Gastroenterol Hepatol, 2018-01-03;5(3):333-352.
Species: Mouse
Sample Types: Organoids
Applications: Organoid Culture -
Generation of iPSC-derived limb progenitor-like cells for stimulating phalange regeneration in the adult mouse
Authors: Y Chen, H Xu, G Lin
Cell Discov, 2017-12-19;3(0):17046.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Transplantation of Gene-Edited Hepatocyte-like Cells Modestly Improves Survival of Arginase-1-Deficient Mice
Authors: YY Sin, LL Ballantyne, CR Richmond, CD Funk
Mol Ther Nucleic Acids, 2017-12-01;10(0):122-130.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates
Authors: MW Susman, EP Karuna, RC Kunz, TS Gujral, AV Cantú, SS Choi, BY Jong, K Okada, MK Scales, J Hum, LS Hu, MW Kirschner, R Nishinakam, S Yamada, DJ Laird, LE Jao, SP Gygi, ME Greenberg, HH Ho
Elife, 2017-09-08;6(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
N-terminal part of Dishevelled DEP domain is required for Wnt/?-catenin signaling in mammalian cells
Authors: P Paclíková, O Bernatík, TW Radaszkiew, V Bryja
Mol. Cell. Biol., 2017-08-28;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors
Authors: KF Cogger, A Sinha, F Sarangi, EC McGaugh, D Saunders, C Dorrell, S Mejia-Guer, Y Aghazadeh, JL Rourke, RA Screaton, M Grompe, PR Streeter, AC Powers, M Brissova, T Kislinger, MC Nostro
Nat Commun, 2017-08-24;8(1):331.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes
Authors: B Li, C Dorrell, PS Canaday, C Pelz, A Haft, M Finegold, M Grompe
Stem Cell Reports, 2017-07-06;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Constructing cellular niche properties by localized presentation of Wnt proteins on synthetic surfaces
Authors: M Lowndes, S Junyent, SJ Habib
Nat Protoc, 2017-06-29;12(7):1498-1512.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency
Authors: YY Sin, PR Price, LL Ballantyne, CD Funk
Sci Rep, 2017-05-31;7(1):2585.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma
Authors: T Tammela, FJ Sanchez-Ri, NM Cetinbas, K Wu, NS Joshi, K Helenius, Y Park, R Azimi, NR Kerper, RA Wesselhoef, X Gu, L Schmidt, M Cornwall-B, ÖH Yilmaz, W Xue, P Katajisto, A Bhutkar, T Jacks
Nature, 2017-05-10;545(7654):355-359.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Neuroprotective and regenerative roles of intranasal Wnt-3a Administration after focal ischemic stroke in mice
Authors: ZZ Wei, JY Zhang, TM Taylor, X Gu, Y Zhao, L Wei
J. Cereb. Blood Flow Metab., 2017-04-21;0(0):271678X177026.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Ganoderma lucidum (Reishi) suppresses proliferation and migration of breast cancer cells via inhibiting Wnt/?-catenin signaling
Authors: Y Zhang
Biochem. Biophys. Res. Commun., 2017-04-17;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling
Authors: KB McCauley, F Hawkins, M Serra, DC Thomas, A Jacob, DN Kotton
Cell Stem Cell, 2017-03-30;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Postnatal Calvarial Skeletal Stem Cells Expressing PRX1 Reside Exclusively in the Calvarial Sutures and Are Required for Bone Regeneration
Authors: K Wilk, SA Yeh, LJ Mortensen, S Ghaffariga, CM Lombardo, SH Bassir, ZA Aldawood, CP Lin, G Intini
Stem Cell Reports, 2017-03-30;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Activation of Wnt3?/?-catenin signal pathway attenuates apoptosis of the cerebral microvascular endothelial cells induced by oxygen-glucose deprivation
Authors: J Zhang, J Zhang, C Qi, P Yang, X Chen, Y Liu
Biochem. Biophys. Res. Commun, 2017-03-25;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Acceleration of bone regeneration by activating Wnt/?-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis
Authors: L Li, X Peng, Y Qin, R Wang, J Tang, X Cui, T Wang, W Liu, H Pan, B Li
Sci Rep, 2017-03-24;7(0):45204.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling
Authors: MB Furtado, JC Wilmanns, A Chandran, J Perera, O Hon, C Biben, TJ Willow, HT Nim, G Kaur, S Simonds, Q Wu, D Willians, E Salimova, N Plachta, JM Denegre, SA Murray, D Fatkin, M Cowley, JT Pearson, D Kaye, M Ramialison, RP Harvey, NA Rosenthal, MW Costa
JCI Insight, 2017-03-23;2(6):e88271.
Species: Human
Sample Types: Cell Lysates
Applications: Bioassay -
Interplay between metabolic identities in the intestinal crypt supports stem cell function
Authors: MJ Rodríguez-, M Schewe, M Meerlo, E Stigter, J Gerrits, M Pras-Raves, A Sacchetti, M Hornsveld, KC Oost, HJ Snippert, N Verhoeven-, R Fodde, BM Burgering
Nature, 2017-03-08;543(7645):424-427.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways
Authors: F Lacour, E Vezin, CF Bentzinger, MC Sincennes, L Giordani, A Ferry, R Mitchell, K Patel, MA Rudnicki, MC Chaboissie, AA Chassot, F Le Grand
Cell Rep, 2017-03-07;18(10):2320-2330.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2
Authors: N Cerdá-Este, H Naumann, S Ruzittu, N Mah, IM Pongrac, C Cozzitorto, A Hommel, MA Andrade-Na, E Bonifacio, FM Spagnoli
Nat Commun, 2017-02-13;8(0):14127.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling.
Authors: Lebensohn A, Dubey R, Neitzel L, Tacchelly-Benites O, Yang E, Marceau C, Davis E, Patel B, Bahrami-Nejad Z, Travaglini K, Ahmed Y, Lee E, Carette J, Rohatgi R
Elife, 2016-12-20;5(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD
Authors: Hoeke A Baarsma
J. Exp. Med, 2016-12-15;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms
Nat. Med, 2016-12-05;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells
Authors: Joan Massagué
Cell Stem Cell, 2016-11-23;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Chemokine-Like Receptor 1 Is a Novel Wnt Target Gene that Regulates Mesenchymal Stem Cell Differentiation.
Authors: Muruganandan S, Govindarajan R, McMullen N, Sinal C
Stem Cells, 2016-11-11;35(3):711-724.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Tissue-Specific Stem Cells Obtained by Reprogramming of Non-Obese Diabetic (NOD) Mouse-Derived Pancreatic Cells Confer Insulin Production in Response to Glucose
PLoS ONE, 2016-09-23;11(9):e0163580.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Retinol Promotes In Vitro Growth of Proximal Colon Organoids through a Retinoic Acid-Independent Mechanism
PLoS ONE, 2016-08-26;11(8):e0162049.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
Pigment Epithelium-derived Factor (PEDF) Blocks Wnt3a-induced Autophagy in Pancreatic Intraepithelial Neoplasms
J Biol Chem, 2016-08-24;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Diverse Functions of Retinoic Acid in Brain Vascular Development
J Neurosci, 2016-07-20;36(29):7786-801.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay -
WNT/?-catenin signaling promotes VSMCs to osteogenic transdifferentiation and calcification through directly modulating Runx2 gene expression
Authors: Ting Cai
Exp Cell Res, 2016-06-16;0(0):.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay -
In Vitro Polarization of Colonoids to Create an Intestinal Stem Cell Compartment
Authors: PJ Attayek, AA Ahmad, Y Wang, I Williamson, CE Sims, ST Magness, NL Allbritton
PLoS ONE, 2016-04-21;11(4):e0153795.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
Wnt Protein Signaling Reduces Nuclear Acetyl-CoA Levels to Suppress Gene Expression during Osteoblast Differentiation
Authors: CM Karner, E Esen, J Chen, FF Hsu, J Turk, F Long
J. Biol. Chem., 2016-04-20;291(25):13028-39.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Trop2 marks transient gastric fetal epithelium and adult regenerating cells after epithelial damage
Authors: Marie-Isabelle Garcia
Development, 2016-03-17;143(9):1452-63.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Convergence of cMyc and beta-catenin on Tcf7l1 enables endoderm specification.
Authors: Morrison G, Scognamiglio R, Trumpp A, Smith A
EMBO J, 2015-12-16;35(3):356-68.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Hepatic progenitor cells of biliary origin with liver repopulation capacity.
Authors: Lu W, Bird T, Boulter L, Tsuchiya A, Cole A, Hay T, Guest R, Wojtacha D, Man T, Mackinnon A, Ridgway R, Kendall T, Williams M, Jamieson T, Raven A, Hay D, Iredale J, Clarke A, Sansom O, Forbes S
Nat Cell Biol, 2015-07-20;17(8):971-83.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Heavy Metal Ion Regulation of Gene Expression: MECHANISMS BY WHICH LEAD INHIBITS OSTEOBLASTIC BONE-FORMING ACTIVITY THROUGH MODULATION OF THE Wnt/beta-CATENIN SIGNALING PATHWAY.
Authors: Beier E, Sheu T, Dang D, Holz J, Ubayawardena R, Babij P, Puzas J
J Biol Chem, 2015-05-14;290(29):18216-26.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis.
Authors: Amador-Arjona, Alejandr, Cimadamore, Flavio, Huang, Chun-Ten, Wright, Rebecca, Lewis, Susan, Gage, Fred H, Terskikh, Alexey V
Proc Natl Acad Sci U S A, 2015-03-30;112(15):E1936-45.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development.
Authors: Chang B, Tessneer K, McManus J, Liu X, Hahn S, Pasula S, Wu H, Song H, Chen Y, Cai X, Dong Y, Brophy M, Rahman R, Ma J, Xia L, Chen H
Nat Commun, 2015-03-16;6(0):6380.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
WNT/beta-Catenin Signaling Regulates Multiple Steps of Myogenesis by Regulating Step-Specific Targets.
Authors: Suzuki A, Pelikan R, Iwata J
Mol Cell Biol, 2015-03-09;35(10):1763-76.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Bioassay -
Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.
Authors: Suryawanshi A, Manoharan I, Hong Y, Swafford D, Majumdar T, Taketo M, Manicassamy B, Koni P, Thangaraju M, Sun Z, Mellor A, Munn D, Manicassamy S
J Immunol, 2015-02-20;194(7):3295-304.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibited Wnt signaling causes age-dependent abnormalities in the bone matrix mineralization in the Apert syndrome FGFR2(S252W/+) mice.
Authors: Zhang L, Chen P, Chen L, Weng T, Zhang S, Zhou X, Zhang B, Liu L
PLoS ONE, 2015-02-18;10(2):e112716.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage.
Authors: Tao S, Tang D, Morita Y, Sperka T, Omrani O, Lechel A, Sakk V, Kraus J, Kestler H, Kuhl M, Rudolph K
EMBO J, 2015-01-21;34(5):624-40.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Differential expression of claudin family members during osteoblast and osteoclast differentiation: Cldn-1 is a novel positive regulator of osteoblastogenesis.
Authors: Alshbool F, Mohan S
PLoS ONE, 2014-12-05;9(12):e114357.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Epigenome-guided analysis of the transcriptome of plaque macrophages during atherosclerosis regression reveals activation of the Wnt signaling pathway.
Authors: Ramsey S, Vengrenyuk Y, Menon P, Podolsky I, Feig J, Aderem A, Fisher E, Gold E
PLoS Genet, 2014-12-04;10(12):e1004828.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Partial maintenance and long-term expansion of murine skin epithelial stem cells by Wnt-3a in vitro.
Authors: Ouji Y, Ishizaka S, Nakamura-Uchiyama F, Okuzaki D, Yoshikawa M
J Invest Dermatol, 2014-12-01;135(6):1598-608.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Induction of tissue-specific stem cells by reprogramming factors, and tissue-specific selection.
Authors: Noguchi, H, Saitoh, I, Tsugata, T, Kataoka, H, Watanabe, M, Noguchi, Y
Cell Death Differ, 2014-09-05;22(1):145-55.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
In vitro generation of neuromesodermal progenitors reveals distinct roles for wnt signalling in the specification of spinal cord and paraxial mesoderm identity.
Authors: Gouti, Mina, Tsakiridis, Anestis, Wymeersch, Filip J, Huang, Yali, Kleinjung, Jens, Wilson, Valerie, Briscoe, James
PLoS Biol, 2014-08-26;12(8):e1001937.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Custos controls beta-catenin to regulate head development during vertebrate embryogenesis.
Authors: Komiya Y, Mandrekar N, Sato A, Dawid I, Habas R
Proc Natl Acad Sci U S A, 2014-08-25;111(36):13099-104.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3.
Authors: Cambier L, Plate M, Sucov H, Pashmforoush M
Development, 2014-08-01;141(15):2959-71.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways.
Authors: Zhu Q, Song L, Peng G, Sun N, Chen J, Zhang T, Sheng N, Tang W, Qian C, Qiao Y, Tang K, Han J, Li J, Jing N
Elife, 2014-06-14;3(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Dose-dependent effect of estrogen suppresses the osteo-adipogenic transdifferentiation of osteoblasts via canonical Wnt signaling pathway.
Authors: Gao B, Huang Q, Lin Y, Wei B, Guo Y, Sun Z, Wang L, Fan J, Zhang H, Han Y, Li X, Shi J, Liu J, Yang L, Luo Z
PLoS ONE, 2014-06-11;9(6):e99137.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging.
Authors: Zhu, Yunhua, Demidov, Oleg N, Goh, Amanda M, Virshup, David M, Lane, David P, Bulavin, Dmitry V
J Clin Invest, 2014-06-09;124(7):3263-73.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Hhex and Cer1 mediate the Sox17 pathway for cardiac mesoderm formation in embryonic stem cells.
Authors: Liu Y, Kaneda R, Leja T, Subkhankulova T, Tolmachov O, Minchiotti G, Schwartz R, Barahona M, Schneider M
Stem Cells, 2014-06-01;32(6):1515-26.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Generation of organized germ layers from a single mouse embryonic stem cell.
Authors: Poh Y, Chen J, Hong Y, Yi H, Zhang S, Chen J, Wu D, Wang L, Jia Q, Singh R, Yao W, Tan Y, Tajik A, Tanaka T, Wang N
Nat Commun, 2014-05-30;5(0):4000.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Transport activity and presence of ClC-7/Ostm1 complex account for different cellular functions.
Authors: Weinert S, Jabs S, Hohensee S, Chan W, Kornak U, Jentsch T
EMBO Rep, 2014-05-12;15(7):784-91.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Manipulating gene expression and signaling activity in cultured mouse limb bud cells.
Authors: Lewandowski J, Pursell T, Rabinowitz A, Vokes S
Dev Dyn, 2014-04-17;243(7):928-36.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength.
Authors: Bentzinger C, von Maltzahn J, Dumont N, Stark D, Wang Y, Nhan K, Frenette J, Cornelison D, Rudnicki M
J Cell Biol, 2014-04-07;205(1):97-111.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Hepatocyte growth factor (Hgf) stimulates low density lipoprotein receptor-related protein (Lrp) 5/6 phosphorylation and promotes canonical Wnt signaling.
Authors: Koraishy F, Silva C, Mason S, Wu D, Cantley L
J Biol Chem, 2014-04-01;289(20):14341-50.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Noncanonical Wnt5a enhances Wnt/beta-catenin signaling during osteoblastogenesis.
Authors: Okamoto M, Udagawa N, Uehara S, Maeda K, Yamashita T, Nakamichi Y, Kato H, Saito N, Minami Y, Takahashi N, Kobayashi Y
Sci Rep, 2014-03-27;4(0):4493.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4.
Authors: Yu C, Nguyen T, Irvine K, Sweet M, Frazer I, Blumenthal A
Eur J Immunol, 2014-03-07;44(5):1480-90.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Distinct Wnt-driven primitive streak-like populations reflect in vivo lineage precursors.
Authors: Tsakiridis, Anestis, Huang, Yali, Blin, Guillaum, Skylaki, Stavroul, Wymeersch, Filip, Osorno, Rodrigo, Economou, Costas, Karagianni, Eleni, Zhao, Suling, Lowell, Sally, Wilson, Valerie
Development, 2014-03-01;141(6):1209-21.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.
Authors: Go G, Srivastava R, Hernandez-Ono A, Gang G, Smith S, Booth C, Ginsberg H, Mani A
Cell Metab, 2014-02-04;19(2):209-20.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
WNT7B promotes bone formation in part through mTORC1.
Authors: Chen J, Tu X, Esen E, Joeng K, Lin C, Arbeit J, Ruegg M, Hall M, Ma L, Long F
PLoS Genet, 2014-01-30;10(1):e1004145.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Beta-catenin is vital for the integrity of mouse embryonic stem cells.
Authors: Raggioli A, Junghans D, Rudloff S, Kemler R
PLoS ONE, 2014-01-21;9(1):e86691.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Canonical WNT signaling inhibits follicle stimulating hormone mediated steroidogenesis in primary cultures of rat granulosa cells.
Authors: Stapp A, Gomez B, Gifford C, Hallford D, Hernandez Gifford J
PLoS ONE, 2014-01-17;9(1):e86432.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay -
Drugging a stem cell compartment using Wnt3a protein as a therapeutic.
Authors: Dhamdhere, Girija R, Fang, Mark Y, Jiang, Jie, Lee, Katherin, Cheng, Du, Olveda, Rebecca, Liu, Bo, Mulligan, Kimberle, Carlson, Jeffery, Ransom, Ryan C, Weis, William, Helms, Jill A
PLoS ONE, 2014-01-06;9(1):e83650.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Intestinal subepithelial myofibroblasts support the growth of intestinal epithelial stem cells.
Authors: Lei N, Jabaji Z, Wang J, Joshi V, Brinkley G, Khalil H, Wang F, Jaroszewicz A, Pellegrini M, Li L, Lewis M, Stelzner M, Dunn J, Martin M
PLoS ONE, 2014-01-06;9(1):e84651.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Flk1+ and VE-cadherin+ endothelial cells derived from iPSCs recapitulates vascular development during differentiation and display similar angiogenic potential as ESC-derived cells.
Authors: Kohler, Erin E, Wary, Kishore, Li, Fei, Chatterjee, Ishita, Urao, Norifumi, Toth, Peter T, Ushio-Fukai, Masuko, Rehman, Jalees, Park, Changwon, Malik, Asrar B
PLoS ONE, 2013-12-30;8(12):e85549.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Pannexin 3 inhibits proliferation of osteoprogenitor cells by regulating Wnt and p21 signaling.
Authors: Ishikawa M, Iwamoto T, Fukumoto S, Yamada Y
J Biol Chem, 2013-12-12;289(5):2839-51.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for Wnt-signaling inhibition.
Authors: Boschert V, van Dinther M, Weidauer S, van Pee K, Muth E, ten Dijke P, Mueller T
PLoS ONE, 2013-11-29;8(11):e81710.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Osteoblast CFTR inactivation reduces differentiation and osteoprotegerin expression in a mouse model of cystic fibrosis-related bone disease.
Authors: Stalvey M, Clines K, Havasi V, McKibbin C, Dunn L, Chung W, Clines G
PLoS ONE, 2013-11-13;8(11):e80098.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties.
Authors: Nishino, Jinsuke, Kim, Sunjung, Zhu, Yuan, Zhu, Hao, Morrison, Sean J
Elife, 2013-11-05;2(0):e00924.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
Postnatal ablation of osteoblast Smad4 enhances proliferative responses to canonical Wnt signaling through interactions with beta-catenin.
Authors: Salazar V, Zarkadis N, Huang L, Watkins M, Kading J, Bonar S, Norris J, Mbalaviele G, Civitelli R
J Cell Sci, 2013-10-07;126(0):5598-609.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/beta-catenin signaling.
Authors: Xavier C, Melikova M, Chuman Y, Uren A, Baljinnyam B, Rubin J
Cell Signal, 2013-09-28;26(1):94-101.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
BMP4 is required for the initial expression of MITF in melanocyte precursor differentiation from embryonic stem cells.
Authors: Yang J, Wang J, Pan L, Li H, Rao C, Zhang X, Niu G, Qu J, Hou L
Exp Cell Res, 2013-09-27;320(1):54-61.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection.
Authors: Zhou, Wei-Jie, Geng, Zhen H, Spence, Jason R, Geng, Jian-Guo
Nature, 2013-07-31;501(7465):107-11.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Evidence for tankyrases as antineoplastic targets in lung cancer.
Authors: Busch A, Johnson K, Stan R, Sanglikar A, Ahmed Y, Dmitrovsky E, Freemantle S
BMC Cancer, 2013-04-28;13(0):211.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CSF-1 receptor-dependent colon development, homeostasis and inflammatory stress response.
Authors: Huynh D, Akcora D, Malaterre J, Chan C, Dai X, Bertoncello I, Stanley E, Ramsay R
PLoS ONE, 2013-02-22;8(2):e56951.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury.
Proc Natl Acad Sci U S A, 2013-01-23;110(6):2324-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells.
Authors: Mae, Shin-Ich, Shono, Akemi, Shiota, Fumihiko, Yasuno, Tetsuhik, Kajiwara, Masatosh, Gotoda-Nishimura, Nanaka, Arai, Sayaka, Sato-Otubo, Aiko, Toyoda, Taro, Takahashi, Kazutosh, Nakayama, Naoki, Cowan, Chad A, Aoi, Takashi, Ogawa, Seishi, McMahon, Andrew P, Yamanaka, Shinya, Osafune, Kenji
Nat Commun, 2013-01-01;4(0):1367.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Pertussis toxin-sensitive heterotrimeric G(alphai/o) proteins mediate WNT/beta-catenin and WNT/ERK1/2 signaling in mouse primary microglia stimulated with purified WNT-3A.
Authors: Halleskog C, Schulte G
Cell Signal, 2012-12-22;25(4):822-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.
Authors: Sneddon, Julie B, Borowiak, Malgorza, Melton, Douglas
Nature, 2012-10-07;491(7426):765-8.
Species: Mouse
Sample Types: Whole Cells
-
Prolactin stimulates precursor cells in the adult mouse hippocampus.
Authors: Walker, Tara L, Vukovic, Jana, Koudijs, Margaret, Blackmore, Daniel G, Mackay, Eirinn W, Sykes, Alex M, Overall, Rupert W, Hamlin, Adam S, Bartlett, Perry F
PLoS ONE, 2012-09-04;7(9):e44371.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Heparan sulfate 6-O-endosulfatases (Sulfs) coordinate the Wnt signaling pathways to regulate myoblast fusion during skeletal muscle regeneration.
Authors: Tran, Thanh H, Shi, Xiaofeng, Zaia, Joseph, Ai, Xingbin
J Biol Chem, 2012-08-03;287(39):32651-64.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the beta-catenin destruction complex.
Authors: Tran H, Polakis P
J Biol Chem, 2012-07-03;287(34):28552-63.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis.
Cell Death Differ., 2012-05-04;19(11):1761-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.
Authors: Goel S, Chin EN, Fakhraldeen SA
J. Biol. Chem., 2012-03-20;287(20):16454-66.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells.
Authors: Wang P, McKnight K, Wong D, Rodriguez R, Sugiyama T, Gu X, Ghodasara A, Qu K, Chang H, Kim S
Stem Cells Dev, 2012-02-29;21(12):2273-87.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5).
Authors: Palsgaard J, Emanuelli B, Winnay JN, Sumara G, Karsenty G, Kahn CR
J. Biol. Chem., 2012-02-15;287(15):12016-26.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA.
Authors: Nakamura, Tetsuya, Saito, Daisuke, Kawasumi, Aiko, Shinohara, Kyosuke, Asai, Yasuko, Takaoka, Katsuyos, Dong, Fenglan, Takamatsu, Atsuko, Belo, Jose Ant, Mochizuki, Atsushi, Hamada, Hiroshi
Nat Commun, 2012-01-01;3(0):1322.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells.
Authors: Kelly OG, Chan MY, Martinson LA
Nat. Biotechnol., 2011-07-31;29(8):750-6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells.
Authors: Tsai SY, Bouwman BA, Ang YS, Kim SJ, Lee DF, Lemischka IR, Rendl M
Stem Cells, 2011-06-01;29(6):964-71.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways.
Authors: Krause C, Korchynskyi O, de Rooij K, Weidauer SE, de Gorter DJ, van Bezooijen RL, Hatsell S, Economides AN, Mueller TD, Lowik CW, ten Dijke P
J. Biol. Chem., 2010-10-15;285(53):41614-26.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies.
Authors: Gong Y, Bourhis E, Chiu C, Stawicki S, DeAlmeida VI, Liu BY, Phamluong K, Cao TC, Carano RA, Ernst JA, Solloway M, Rubinfeld B, Hannoush RN, Wu Y, Polakis P, Costa M
PLoS ONE, 2010-09-13;5(9):e12682.
Species: Human
Sample Types: Recombinant Protein
Applications: Binding Assay -
Notch and Wnt signaling mediated rod photoreceptor regeneration by Muller cells in adult mammalian retina.
Authors: Del Debbio CB, Balasubramanian S, Parameswaran S, Chaudhuri A, Qiu F, Ahmad I
PLoS ONE, 2010-08-26;5(8):e12425.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells.
Authors: Roelandt P, Pauwelyn KA, Sancho-Bru P
PLoS ONE, 2010-08-11;5(8):e12101.
Species: Rat
Sample Types: Whole Cells
Applications: Cell Culture -
Wnt3a activates dormant c-Kit(-) bone marrow-derived cells with short-term multilineage hematopoietic reconstitution capacity.
Authors: Trowbridge JJ, Guezguez B, Moon RT
Stem Cells, 2010-08-01;28(8):1379-89.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos.
Authors: Kawaguchi J, Nichols J, Gierl MS, Faial T, Smith A
Development, 2010-03-01;137(5):693-704.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Activation of canonical wingless-type MMTV integration site family (Wnt) signaling in mature adipocytes increases beta-catenin levels and leads to cell dedifferentiation and insulin resistance.
Authors: Gustafson B, Smith U
J. Biol. Chem., 2010-02-23;285(18):14031-41.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Canonical Wnt signaling negatively regulates platelet function.
Authors: Steele BM, Harper MT, Macaulay IC, Morrell CN, Perez-Tamayo A, Foy M, Habas R, Poole AW, Fitzgerald DJ, Maguire PB
Proc. Natl. Acad. Sci. U.S.A., 2009-11-09;106(47):19836-41.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Wnt signaling mediates experience-related regulation of synapse numbers and mossy fiber connectivities in the adult hippocampus.
Authors: Gogolla N, Galimberti I, Deguchi Y, Caroni P
Neuron, 2009-05-28;62(4):510-25.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells.
Authors: Hansson M, Olesen DR, Peterslund JM, Engberg N, Kahn M, Winzi M, Klein T, Maddox-Hyttel P, Serup P
Dev. Biol., 2009-04-07;330(2):286-304.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.
Authors: Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA
Cell Stem Cell, 2009-04-03;4(4):348-58.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cooperative folding and ligand-binding properties of LRP6 beta-propeller domains.
Authors: Liu CC, Pearson C, Bu G
J. Biol. Chem., 2009-03-31;284(22):15299-307.
Species: Human
Sample Types: N/A, Whole Cells
Applications: Bioassay, Receptor Binding Assay -
H-Ras is degraded by Wnt/beta-catenin signaling via beta-TrCP-mediated polyubiquitylation.
Authors: Kim SE, Yoon JY, Jeong WJ, Jeon SH, Park Y, Yoon JB, Park YN, Kim H, Choi KY
J. Cell. Sci., 2009-02-24;122(0):842-8.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Transcriptional regulation of SM22alpha by Wnt3a: convergence with TGFbeta(1)/Smad signaling at a novel regulatory element.
Authors: Shafer SL, Towler DA
J. Mol. Cell. Cardiol., 2009-01-21;46(5):621-35.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Parathyroid hormone signaling through low-density lipoprotein-related protein 6.
Authors: Wan M, Yang C, Li J, Wu X, Yuan H, Ma H, He X, Nie S, Chang C, Cao X
Genes Dev., 2008-11-01;22(21):2968-79.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
The microRNA miR-8 is a conserved negative regulator of Wnt signaling.
Authors: Kennell JA, Gerin I, MacDougald OA, Cadigan KM
Proc. Natl. Acad. Sci. U.S.A., 2008-09-29;105(40):15417-22.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells.
Authors: Verkaar F, van Rosmalen JW, Smits JF, Blankesteijn WM, Zaman GJ
Cell. Signal., 2008-09-25;21(1):22-33.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Directed induction of anterior and posterior primitive streak by Wnt from embryonic stem cells cultured in a chemically defined serum-free medium.
Authors: Nakanishi M, Kurisaki A, Hayashi Y, Warashina M, Ishiura S, Kusuda-Furue M, Asashima M
FASEB J., 2008-09-22;23(1):114-22.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism.
Authors: Endo Y, Beauchamp E, Woods D, Taylor WG, Toretsky JA, Uren A, Rubin JS
Mol. Cell. Biol., 2008-01-22;28(7):2368-79.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage.
Authors: Elkabetz Y, Panagiotakos G, Al Shamy G, Socci ND, Tabar V, Studer L
Genes Dev., 2008-01-15;22(2):152-65.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Myogenic growth factors can decrease extraocular muscle force generation: a potential biological approach to the treatment of strabismus.
Authors: Anderson BC, Christiansen SP, McLoon LK
Invest. Ophthalmol. Vis. Sci., 2008-01-01;49(1):221-9.
Species: Rabbit
Sample Types: In Vivo
Applications: In Vivo -
Betacellulin and nicotinamide sustain PDX1 expression and induce pancreatic beta-cell differentiation in human embryonic stem cells.
Authors: Cho YM, Lim JM, Yoo DH, Kim JH, Chung SS, Park SG, Kim TH, Oh SK, Choi YM, Moon SY, Park KS, Lee HK
Biochem. Biophys. Res. Commun., 2007-12-04;366(1):129-34.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells.
Authors: Zhang P, Li J, Tan Z, Wang C, Liu T, Chen L, Yong J, Jiang W, Sun X, DU L, Ding M, Deng H
Blood, 2007-11-27;111(4):1933-41.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Production of Wnt inhibitors by myeloma cells: potential effects on canonical Wnt pathway in the bone microenvironment.
Authors: Giuliani N, Morandi F, Tagliaferri S, Lazzaretti M, Donofrio G, Bonomini S, Sala R, Mangoni M, Rizzoli V
Cancer Res., 2007-08-15;67(16):7665-74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors.
Authors: Kwon C, Arnold J, Hsiao EC, Taketo MM, Conklin BR, Srivastava D
Proc. Natl. Acad. Sci. U.S.A., 2007-06-18;104(26):10894-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia.
Authors: Rydziel S, Stadmeyer L, Zanotti S, Durant D, Smerdel-Ramoya A, Canalis E
J. Biol. Chem., 2007-05-10;282(27):19762-72.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Wnt3a binds to several sFRPs in the nanomolar range.
Authors: Wawrzak D, Metioui M, Willems E, Hendrickx M, de Genst E, Leyns L
Biochem. Biophys. Res. Commun., 2007-04-19;357(4):1119-23.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.
Authors: Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M
Proc. Natl. Acad. Sci. U.S.A., 2007-03-19;104(13):5668-73.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Sustained interactive Wnt and FGF signaling is required to maintain isthmic identity.
Authors: Canning CA, Lee L, Irving C, Mason I, Jones CM
Dev. Biol., 2007-02-16;305(1):276-86.
Species: Chicken
Sample Types: Whole Tissue
Applications: Bioassay -
An early role for WNT signaling in specifying neural patterns of Cdx and Hox gene expression and motor neuron subtype identity.
Authors: Nordstrom U, Maier E, Jessell TM, Edlund T
PLoS Biol., 2006-07-01;4(8):e252.
Species: Chicken
Sample Types: Whole Tissue
Applications: Bioassay -
Wnt3a gradient converts radial to bilateral feather symmetry via topological arrangement of epithelia.
Authors: Yue Z, Jiang TX, Widelitz RB, Chuong CM
Proc. Natl. Acad. Sci. U.S.A., 2006-01-17;103(0):951-5.
Species: Chicken
Sample Types: In Vivo
Applications: In Vivo -
Multipotentiality, homing properties, and pyramidal neurogenesis of CNS-derived LeX(ssea-1)+/CXCR4+ stem cells.
Authors: Corti S, Locatelli F, Papadimitriou D, Donadoni C, Del Bo R, Fortunato F, Strazzer S, Salani S, Bresolin N, Comi GP
FASEB J., 2005-09-08;19(13):1860-2.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay
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Average Rating: 4.1 (Based on 7 Reviews)
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Reason for Rating: Consistent and expect bioactive in our cell culture assays. Also expected protein concentration
Use rec Wnt in the growth and differentiation of cultures.
Reason for Rating: reproducible results