Recombinant Viral Zika Virus (MR 766) NS1 Protein, CF
Recombinant Viral Zika Virus (MR 766) NS1 Protein, CF Summary
Product Specifications
Val792 & Ser795-Ser1144, with a C-terminal 6-His tag
Analysis
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Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
9445-ZK
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
| Reconstitution | Reconstitute at 500 μg/mL in PBS. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Background: Zika Virus (MR 766) NS1
Zika Virus non-structural protein 1 (ZIKV NS1) is an approximately 48 kDa viral glycoprotein (1). Zika Virus is a mosquito-borne flavivirus and has been implicated an association with neonatal microcephaly and neurological disorders such as Guillain-Barré syndrome (2). ZIKV strain MR 766 was isolated from monkey host. ZIKV NS1 is a multifunctional virulence factor. The glycosylated NS1 exists as a membrane-associated dimer after translocation into the endoplasmic reticulum lumen, where it is essential for viral genome replication (1, 2). Infected cells secrete NS1 as a lipoprotein, which is involved in immune evasion and pathogenesis via interaction with components of the innate and adaptive immune systems (1, 2). Mature ZIKV NS1 contains 352 amino acids (aa) and has a hexameric conformation consisting of three dimers to form a symmetric barrel shape (1). It has high structural similarity to other flavivirus NS1 proteins, such as DENV and WNV (2, 3). Mature NS1 of ZIKV strain MR 766 shares 98% aa sequence identity with NS1 of ZIKV strain H/PF/2013 that was isolated from human host.
- Song, H. et al. (2016) Nat. Struct. and Mol. Biol. 23:456.
- Brown, WC. et al. (2016) Nat. Struct. and Mol. Biol. 23: 865.
- Baronti, C. et al. (2014) Genome Announc. 2: e00500
Citation for Recombinant Viral Zika Virus (MR 766) NS1 Protein, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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High-affinity five/six-letter DNA aptamers with superior specificity enabling the detection of dengue NS1 protein variants beyond the serotype identification
Authors: KI Matsunaga, M Kimoto, VW Lim, HP Tan, YQ Wong, W Sun, S Vasoo, YS Leo, I Hirao
Nucleic Acids Research, 2021-11-18;0(0):.
Species: Human
Sample Types: Protein
Applications: ELISA Capture
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