Remacemide hydrochloride

Biological Activity

Remacemide hydrochloride is an non-competitive NMDA receptor antagonist; blocks ion channel and allosteric modulatory site (IC₅₀ = 8 - 68 mM). Remacemide hydrochloride is anticonvulsant in vivo and metabolizes to a more potent desglycine analog. Weakly blocks voltage-dependent Na⁺ channels (IC₅₀ = 161 mM). In an animal model of Huntington's disease, extends survival and delays disease; this effect is more pronounced when combined with Coenzyme Q10 (Cat. No. 3003)

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. Na⁺ channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes.
   Santangeli et al.
   Eur.J.Pharmacol., 2002;438:63
2. Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride.
   Palmer et al.
   Ann.N.Y.Acad.Sci., 1995;765:236
3. Block of the N-MthD.-aspartate receptor by remacemide and its des-glycine metabolite.
   Subramaniam et al.
   J.Pharmacol.Exp.Ther., 1996;276:161

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