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Retigabine

Catalog #: 6233
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6233/10
6233/50
Retigabine | CAS No. 150812-12-7 | Voltage-gated Potassium Channel Activators
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Description: KV7 channel activator
Alternative Names: Ezogabine

Chemical Name: Ethyl [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]carbamate

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Retigabine is a KV7 (KCNQ) channel activator (EC50 values are 0.6 - 100 μM for KV7.1 - KV7.5). Anticonvulsant. Orally bioavailable.

Technical Data

M.Wt:
303.33
Formula:
C16H18FN3O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
150812-12-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Retigabine: chemical synthesis to clinical application.
    Blackburn-Munro et al.
    CNS Drug Rev., 2005;11:1

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for Retigabine

The citations listed below are publications that use Tocris products. Selected citations for Retigabine include:

1 Citation: Showing 1 - 1

  1. Molecular expression and pharmacological evidence for a functional role of kv7 channel subtypes in Guinea pig urinary bladder smooth muscle.
    Authors: Afeli Et al.
    PLoS One  2013;8:e75875

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