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RF 9

Catalog #: 3672
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3672/1
RF 9 | CAS No. 876310-60-0 | Neuropeptide FF/AF Receptor Antagonists
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Description: Selective NPFF1 and NPFF2 antagonist

Purity: ≥95%

Product Details
Citations (3)
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Biological Activity

RF 9 is a selective NPFF receptor antagonist (Ki values are 58 and 75 nM at hNPFF1 and hNPFF2 receptors respectively). Displays selectivity over several related receptors including NPY Y1 GPR10, GPR54, GPR103 and the opioid receptors. Blocks NPFF-induced hypothermia and increases in atrial blood pressure and heart rate, and prevents opioid-induced tolerance associated with hyperalgesia in vivo.

Technical Data

M.Wt:
482.62
Formula:
C26H38N6O3
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
876310-60-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The human gonadotropin-inhibitory hormone ortholog RFamide-related peptide-3 suppresses gonadotropin-induced progesterone production in human granulosa cells.

    Endocrinology, 2012;153(7):3435-45.
  2. Neuropeptide FF receptors antagonist, RF9, attenuates opioid-evoked hypothermia in mice.
    Wang et al.
    Peptides, 2008;29:1183
  3. RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia.
    Simonin et al.
    Proc.Natl.Acad.Sci.USA, 2006;103:466
  4. Inhibition of neuropeptide FF (NPFF)-induced hypothermia and anti-morphine analgesia by RF9, a new selective NPFF receptors antagonist.
    Fang et al.
    Regul.Peptides, 2008;147:45

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Citations for RF 9

The citations listed below are publications that use Tocris products. Selected citations for RF 9 include:

3 Citations: Showing 1 - 3

  1. RFRP-3 Influences Apoptosis and Steroidogenesis of Yak Cumulus Cells and Compromises Oocyte Meiotic Maturation and Subsequent Developmental Competence.
    Authors: Jian Et al.
    Int J Mol Sci  2023;24
  2. Genetic and neuronal regulation of sleep by neuropeptide VF.
    Authors: Lee Et al.
    Elife  2017;6
  3. Novel vasocontractile role of the P2Y14 receptor: characterization of its signalling in porcine isolated pancreatic arteries.
    Authors: Alsaqati Et al.
    Br J Pharmacol  2014;171:701

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