Rifampicin
Chemical Name: 3-[[(4-Methyl-1-piperazinyl)imino]methyl]-rifamycin
Purity: ≥95%
Biological Activity
Rifampicin is an antibiotic; inhibits bacterial RNA polymerase. Prototypical activator of the pregnane X receptor (PXR).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Rifampin: mechanisms of action and resistance.
Wehrli
Rev.Infect.Dis., 1983;5:S407 -
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands.
Moore et al.
J.Biol.Chem., 2000;275:15122 -
Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Artsimovitch et al.
Cell, 2005;122:351 -
Pregnane X receptor is SUMOylated to repress the inflammatory response.
Hu et al.
J.Pharmacol.Exp.Ther., 2010;335:342
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