Rilmenidine hemifumarate
Chemical Name: 2-[N-(Dicyclopropylmethyl)amino]oxazoline hemifumarate
Purity: ≥98%
Biological Activity
Rilmenidine hemifumarate is an I1-imidazoline binding site selective ligand and α2-adrenoceptor agonist. Possesses greater I1 vs α2 selectivity than the prototypical compound, clonidine. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.
Williams et al.
Nat.Chem.Biol., 2008;4:295 -
Rilmenidine selectivity for imidazoline receptors in human brain.
Bricca et al.
Eur.J.Pharmacol., 1989;163:373 -
Antiarrhythmic action of rilmenidine on adrenaline-induced arrhythmia via central imidazoline receptors in halothane-anaesthetized dogs.
Mammoto et al.
Br.J.Pharmacol., 1996;117:1744 -
Keeping an eye on the I site: imidazoline-preferring receptors.
Michel and Ernsberger
TIPS, 1992;13:369 -
Human brain imidazoline receptors: Further characterisation with [3H] clon.
Bricca et al.
Eur.J.Pharmacol., 1994;266:25
Product Datasheets
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Citation for Rilmenidine hemifumarate
The citations listed below are publications that use Tocris products. Selected citations for Rilmenidine hemifumarate include:
1 Citation: Showing 1 - 1
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Activation of I(2)-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors.
Authors: Sánchez-Blázquez Et al.
Br J Pharmacol 2000;130:146
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