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RITA

Catalog #: 2443
1 Citation Datasheet / COA / SDS
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2443/1
2443/10
RITA | CAS No. 213261-59-7 | p53 Activators
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Description: MDM2-p53 interaction inhibitor
Alternative Names: NSC 652287

Chemical Name: 5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol

Purity: ≥97%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

RITA is an anti-tumor agent that binds wild-type p53 (Kd = 1.5 nM) preventing p53-MDM2 (HDM2) interaction. Induces p53 accumulation and stimulates apoptosis in tumor cell lines expressing wild-type p53 in vitro and in vivo. Inhibits HPV-E6-mediated proteasomal degradation. Suppresses expression of cervical carcinoma HeLa xenografts in vivo.

Technical Data

M.Wt:
292.37
Formula:
C14H12O3S2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
213261-59-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism.
    Rivera et al.
    Biochem.Pharmacol., 1999;57:1283
  2. Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation.
    Zhao et al.
    Cancer Res., 2010;70:3372
  3. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumours.
    Issaeva et al.
    Nature Med., 2004;10:1321
  4. Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer.
    Espinoza-Fonseca
    Theor.Biol.Med.Mod., 2005;2:38

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Citation for RITA

The citations listed below are publications that use Tocris products. Selected citations for RITA include:

1 Citation: Showing 1 - 1

  1. Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway.
    Authors: Thotala Et al.
    Cell Death Differ  2012;19:387

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