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RMR-Tre

Catalog #: 8013 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8013/2
RMR-Tre | Fluorescent Probes for Imaging Bacteria
2 Images
Description: Far-red fluorogenic trehalose probe for live mycobacteria imaging

Chemical Name: 3-(6-(5-(2,2-Dicyanovinyl)thiophen-2-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-(((2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)methyl)propanamide

Purity: ≥95%

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Biological Activity

RMR-Tre is a far-red fluorogenic trehalose specific probe for live mycobacteria imaging. It enables fast, no-wash, low-background fluorescence detection of live mycobacterial outer membrane. RMR-Tre contains a molecular rotor fluorophore that brightly emits signal in the far-red region upon trehalose-guided metabolic integration into the mycomembrane. It exhibited up to a 100- fold enhancement in Mycobacterium tuberculosis labeling compared to existing fluorogenic trehalose probes. Excitation and emission maxima (λ) are 549 nm and 571 nm, respectively.

Scientific Data

Fluorescence Imaging Far-red fluorogenic trehalose probe for live mycobacteria imaging View Larger

Application of RMR-Tre. Image shows fluorescence detection of live mycobacterial outer membrane: M. smegmatis were incubated for 1 h in the presence of 100 μM of RMR-Tre, then directly imaged by fluorescence microscopy without washing. Scale bar: 10 μm.

Optical Data for RMR-Tre

RMR-Tre Dye Spectra
Emission Color Far Red
λabs 536 nm
λem 684 nm
Closest Laser line 540 nm

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Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

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Technical Data

M.Wt:
686.73
Formula:
C32H38N4O11S
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Central Michigan University

Product Datasheets

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