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RN 1734

Catalog #: 3746
14 Citations Datasheet / COA / SDS
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3746/5
RN 1734 | CAS No. 946387-07-1 | TRPV Antagonists
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Description: Selective TRPV4 antagonist

Chemical Name: 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide

Product Details
Citations (14)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

RN 1734 is a selective TRPV4 antagonist (IC50 values are 2.3, 3.2 and 5.9 μM for hTRPV4, rTRPV4 and mTRPV4 receptors respectively). Displays selectivity for TRPV4 over other TRP channels (IC50 values are 2.3, >30, >30 and >100 μM for TRPV4, TRPV3, TRPM8 and TRPV1 respectively). Blocks TRPV4-mediated arteriole vasodilation and increases myogenic tone ex vivo.

Technical Data

M.Wt:
353.31
Formula:
C14H22Cl2N2O2S
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Storage:
Store at +4°C
CAS No:
946387-07-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone.
    Bagher et al.
    Proc.Natl.Acad.Sci.U.S.A., 2012;109:18174
  2. Identification and characterization of novel TRPV4 modulators.
    Vincent et al.
    Biochem.Biophys.Res.Comms., 2009;389:490
  3. Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men
    RM Samuel, H Majd, MN Richter, Z Ghazizadeh, SM Zekavat, A Navickas, JT Ramirez, H Asgharian, CR Simoneau, LR Bonser, KD Koh, M Garcia-Kni, M Tassetto, S Sunshine, S Farahvashi, A Kalantari, W Liu, R Andino, H Zhao, P Natarajan, DJ Erle, M Ott, H Goodarzi, F Fattahi
    Cell Stem Cell, 2020;27(6):876-889.e12.

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Citations for RN 1734

The citations listed below are publications that use Tocris products. Selected citations for RN 1734 include:

14 Citations: Showing 1 - 10

  1. TRPV4 antagonists ameliorate ventriculomegaly in a rat model of hydrocephalus.
    Authors: Joon W Et al.
    JCI Insight  2020;5
  2. TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation.
    Authors: Stephen J Et al.
    J Clin Invest  2020;130:2527-2541
  3. TRPV4 is the temperature-sensitive ion channel of human sperm.
    Authors: Mundt Et al.
    Elife  2018;7
  4. Involvement of VNUT-exocytosis in transient receptor potential vanilloid 4-dependent ATP release from gastrointestinal epithelium.
    Authors: Mihara Et al.
    PLoS One  2018;13:e0206276
  5. A modular platform for differentiation of human PSCs into all major ectodermal lineages.
    Authors: Tchieu Et al.
    Cell Stem Cell.  2017;21:399
  6. The depressor response to intracerebroventricular hypotonic saline is sensitive to TRPV4 antagonist RN1734.
    Authors: Feetham Et al.
    Cephalalgia  2015;6:83
  7. TRPV4 activates autonomic and behavioural warmth-defence responses in Wistar rats.
    Authors: Vizin Et al.
    Acta Physiol  2015;214:275
  8. Co-administration of transient receptor potential vanilloid 4 (TRPV4) and TRPV1 antagonists potentiate the effect of each drug in a rat model of cystitis.
    Authors: Francisco Et al.
    BJU Int  2015;115:452-60
  9. Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice.
    Authors: Mueller-Tribbensee Et al.
    PLoS One  2015;10:e0128242
  10. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium.
    Authors: Shabir Et al.
    Front Pharmacol  2013;305:F396

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