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RN 9893 hydrochloride

Catalog #: 5678 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5678/10
5678/50
RN 9893 hydrochloride | CAS No. 2109450-40-8 | TRPV Antagonists
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Description: Potent and selective TRPV4 antagonist

Chemical Name: N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamide hydrochloride

Purity: ≥99%

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Biological Activity

RN 9893 hydrochloride is a potent and selective TRPV4 antagonist (IC50 values are 320, 420 and 660 nM for mouse, human and rat channels, respectively). Exhibits >15-fold selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8, and a panel of 54 other common biological targets. Orally bioavailable.

Technical Data

M.Wt:
536.95
Formula:
C21H23F3N4O5S.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
2109450-40-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of orally-bioavailable antagonists of the TRPV4 ion-channel.
    Wei et al.
    Bioorg.Med.Chem.Lett., 2015;25:4011

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