Ro 04-5595 hydrochloride
Chemical Name: 1-[2-(4-Chlorophenyl)ethyl]-1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinol hydrochloride
Purity: ≥98%
Biological Activity
Ro 04-5595 hydrochloride is a selective antagonist for GluN2B (formally NR2B) containing NMDA receptors (Ki = 31 nM).Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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In vitro binding properties in rat brain of [3H] Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits.
Mutel et al.
J.Neurochem., 1998;70:214
Product Datasheets
Citation for Ro 04-5595 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Ro 04-5595 hydrochloride include:
1 Citation: Showing 1 - 1
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Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: A role for NMDA receptors
Authors: Voyer
Neuropharmacology 2017;112:150
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