Ro 51
Chemical Name: 2-[[4-Amino-5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinyl]amino]-1,3-propanediol
Purity: ≥98%
Biological Activity
Ro 51 is a potent, dual P2X3 and P2X2/3 antagonist (IC50 values are 2 and 5 nM for rP2X3 and hP2X2/3 respectively). Selective for P2X3 and P2X2/3 over other P2X receptors (IC50 values are > 10 μM for P2X1, P2X2, P2X4, P2X5, and P2X7). Cell permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X3/P2X2/3 antagonist for the treatment of pain.
Jahangir et al.
Bioorg.Med.Chem.Lett., 2009;19:1632 -
Pharmacology of P2X receptors
Syed and Kennedy
WIREs.Membr.Transp.Signal., 2012;1:16 -
Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons
VB Lu, J Rievaj, EA O'Flaherty, CA Smith, R Pais, LA Pattison, G Tolhurst, AB Leiter, DC Bulmer, FM Gribble, F Reimann
Nat Commun, 2019;10(1):1029.
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Citation for Ro 51
The citations listed below are publications that use Tocris products. Selected citations for Ro 51 include:
1 Citation: Showing 1 - 1
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Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons.
Authors: Lu Et al.
Nat.Commun. 2019;10:1029
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