RO 5263397 hydrochloride
Chemical Name: (4S)-4-(3-Fluoro-2-methylphenyl)-4,5-dihydro-2-oxazolamine hydrochloride
Purity: ≥98%
Biological Activity
RO 5263397 hydrochloride is a potent trace amine 1 (TA1) receptor agonist (EC50 values are 0.12, 35 and 17-85 nM for mouse, rat and human receptors, respectively). Increases wakefulness and reduces REM and NREM sleep duration in wild type mice. Inhibits spontaneous locomotor activity in dopamine transport (DAT) knockout mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Biochemical and functional characterization of the trace amine-associated receptor 1 (TAAR1) agonist RO5263397.
Espinoza et al.
Front.Pharmacol., 2018;9:645 -
Discovery and characterization of 2-aminooxazolines as highly potent, selective, and orally active TAAR1 agonists.
Galley et al.
ACS.Med.Chem.Letts., 2015;7:192 -
Trace amine-associated receptor 1 regulates wakefulness and EEG spectral composition.
Schwartz et al.
Neuropsychopharmacology., 2017;42:1305
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