Ro 8-4304 hydrochloride
Chemical Name: 4-[3-[4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1(2H)-pyridinyl]-2-hydroxypropoxy]benzamide hydrochloride
Purity: ≥99%
Biological Activity
NMDA receptor antagonist (IC50 = 0.4 μM) that displays > 100 fold selectivity for GluN2B (formally NR2B) containing receptors over GluN2A (formally NR2A) containing receptors. Exhibits an activity-dependent mechanism of NMDA antagonism and is competitive with respect to spermine (Cat. No. 0958).Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist.
Kew et al.
Br.J.Pharmacol., 1998;123:463 -
An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones.
Kew and Kemp
J.Physiol., 1998;512:17
Product Datasheets
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Ro 8-4304 hydrochloride
There are currently no reviews for this product. Be the first to review Ro 8-4304 hydrochloride and earn rewards!
Have you used Ro 8-4304 hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
