Home / Sphingosine-1-phosphate Receptor Agonists / RP 001 hydrochloride

RP 001 hydrochloride

Catalog #: 4289
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4289/10
4289/50
RP 001 hydrochloride | CAS No. 1781880-34-9 | Sphingosine-1-phosphate Receptor Agonists
1 Image
Description: Potent S1P1 agonist

Chemical Name: N-[4-[5-[3-Cyano-4-(1-methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]-β-alanine hydrochloride

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

RP 001 hydrochloride is a potent agonist of S1P1 receptors (EC50 = 9 pM). Induces internalization and polyubiquitination of S1P1 in vitro. Selective for S1P1 over S1P2 - S1P4.

Technical Data

M.Wt:
468.93
Formula:
C24H24N4O4.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1781880-34-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A sphingosine-1-phosphate receptor 1 agonist inhibits tertiary lymphoid tissue reactivation and hypersensitivity in the lung
    CA Huppé, P Blais Leco, A Lechasseur, DR Gendron, AM Lemay, EY Bissonnett, MR Blanchet, C Duchaine, MC Morissette, H Rosen, D Marsolais
    Mucosal Immunol, 2017;0(0):.
  2. Actions of a picomolar short-acting S1P1 agonist in S1P1-eGFP knock-in mice.
    Cahalan et al.
    Nat.Chem.Biol., 2011;7:254

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for RP 001 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for RP 001 hydrochloride include:

2 Citations: Showing 1 - 2

  1. RP001 hydrochloride improves neurological outcome after subarachnoid hemorrhage.
    Authors: Li Et al.
    J.Neurol.Sci.  2019;399:6
  2. Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production.
    Authors: Masato Et al.
    Cell  2018;174:636-648.e18

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for RP 001 hydrochloride

There are currently no reviews for this product. Be the first to review RP 001 hydrochloride and earn rewards!

Have you used RP 001 hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.