Home / 5-HT1 Receptor Agonists / RU 24969 hemisuccinate

RU 24969 hemisuccinate

Catalog #: 0912
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0912/10
0912/50
RU 24969 hemisuccinate | CAS No. 66611-27-6 | 5-HT1 Receptor Agonists
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Description: 5-HT1A and 5-HT1B agonist

Chemical Name: 5-Methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole hemisuccinate

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

RU 24969 hemisuccinate is a potent 5-HT1A/1B and moderate 5-HT2C agonist that may also release 5-HT. Centrally active following systemic administration.

Technical Data

M.Wt:
287.34
Formula:
C14H16N2O.½C4H6O4
Solubility:
Soluble to 50 mM in DMSO and to 30 mM in water
Purity:
≥99%
Storage:
Store at RT
CAS No:
66611-27-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Human S31 serotonin receptor clone encodes a 5-hydroxytryptamine1E-like serotonin receptor.
    Gudermann et al.
    Mol.Pharmacol., 1993;43:412
  3. Effect of 5-HT1B receptor ligands on self-administration of ethanol in an operant procedure in rats.
    Tomkins and O'Neill
    Pharmacol.Biochem.Behav., 2000;66:129
  4. Synthesis of 3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles and study of their serotonergic and antiDArgic properties.
    Guillaume et al.
    Eur.J.Med.Chem., 1987;22:33

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Citation for RU 24969 hemisuccinate

The citations listed below are publications that use Tocris products. Selected citations for RU 24969 hemisuccinate include:

1 Citation: Showing 1 - 1

  1. Effects of oxyt. on Serotonin 1B Agonist-induced Autism-like Behavior in Mice
    Authors: Lawson Et al.
    Behavioural Brain Research  2016;314:52

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