RU 28318, potassium salt
Discontinued Product
Chemical Name: (7α,17α)-17-Hydroxy-3-oxo-7-propylpregn-4-ene-21-carboxylic acid, potassium salt
Purity: ≥98%
Biological Activity
RU 28318, potassium salt is a potent and selective antagonist for the mineralocorticoid receptor (MR). Inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. Also decreases blood pressure in female rats following central administration in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Evaluation of RU28318 and RU40555 as selective mineralocorticoid receptor and glucocorticoid receptor antagonists, respectively: receptor measures and functional studies.
Kim et al.
J.Steroid Biochem.Mol.Biol., 1998;67:213 -
The effect of the antimineralocorticoid RU 28318 on aldosterone biosythesis in vitro.
Perroteau et al.
J.Steroid Biochem., 1984;20:853 -
Cardiovascular and renal effects of central administration of a mineralocorticoid receptor antagonist in concious female rats.
Rahmouni et al.
Eur.J.Pharmacol., 1999;385:199
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Citations for RU 28318, potassium salt
The citations listed below are publications that use Tocris products. Selected citations for RU 28318, potassium salt include:
6 Citations: Showing 1 - 6
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Transient receptor potential canonical (TRPC)/Orai1-dependent store-operated Ca2+ channels: New targets of aldosterone in cardiomyocytes.
Authors: Sabourin Et al.
J.Biol.Chem. 2016;291:13394
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Stress-induced memory retrieval impairments: different time-course involvement of corticosterone and glucocorticoid receptors in dorsal and ventral hippocampus.
Authors: Dorey Et al.
Neuropsychopharmacology 2012;37:2870
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Aldosterone decreases glucose-stimulated Ins secretion in vivo in mice and in murine islets.
Authors: Luther Et al.
Diabetologia 2011;54:2152
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Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton.
Authors: Mayanagi Et al.
J Biol Chem 2008;283:31183
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Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake.
Authors: Yang Et al.
Proc Natl Acad Sci U S A 2005;25:4288
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Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation.
Authors: Crochemore Et al.
J Neurosci 2005;10:790
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