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RU-SKI 43 hydrochloride

Catalog #: 4886 Datasheet / COA / SDS

Discontinued Product

4886 has been discontinued.
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RU-SKI 43 hydrochloride | Hedgehog Signaling Inhibitors
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Description: Hedgehog acyltransferase (Hhat) inhibitor; cell permeable

Chemical Name: 2-((2-Methylbutyl)amino)-1-(4-((3-methylphenoxy)methyl-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone hydrochloride

Purity: ≥98%

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Biological Activity

RU-SKI 43 hydrochloride is a hedgehog acyltransferase (Hhat) inhibitor (IC50 = 850 nM). Inhibits Sonic Hedgehog N (ShhN) palmitoylation in vitro. Has no effect on porcupine-induced fatty acid acylation of Wnt39a. Attenuates pancreatic cancer cell proliferation. Cell permeable.

Technical Data

M.Wt:
423.01
Formula:
C22H30N2O2S.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling.
    Petrova et al.
    Nat.Chem.Biol., 2013;9:247
  2. Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma.
    Petrova et al.
    Oncogene, 2014;34:263

Product Datasheets

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