RuBi-GABA

Biological Activity

RuBi-GABA is a ruthenium-bipyridine-triphenylphosphine caged GABA (Cat. No. 0344) that is excited by visible wavelengths. Provides greater tissue penetration, less phototoxicity, faster photorelease kinetics and better spatial resolution than UV light-sensitive caged compounds. Produces GABA receptor-mediated currents in pyramidal neurons in vitro and displays no effect on endogenous GABAergic or glutamatergic transmission at concentrations effective for uncaging.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage.
   Zayat et al.
   J.Am.Chem.Soc., 2003;125:882
2. Photorelease of GABA with visible light using an inorganic caging group.
   Rial Verde et al.
   Front.Neural Circuits, 2008;2:2

Product Datasheets