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(S)-(-)-5-Iodowillardiine

Catalog #: 0307
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0307/10
0307/50
(S)-(-)-5-Iodowillardiine | CAS No. 140187-25-3 | Kainate Receptor Agonists
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Description: Highly potent and subtype-selective kainate agonist

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity

Demonstrates high affinity for the kainate receptor subtype hGluK1 (formerly hGluR5) (Ki = 0.24 nM) and 600-4000-fold selectivity over both the AMPA receptor subtypes and the homomeric kainate receptor hGluK2 (formerly hGluR6).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

M.Wt:
325.06
Formula:
C7H8IN3O4
Solubility:
Soluble to 25 mM in 1.1eq. NaOH
Purity:
≥98%
Storage:
Store at RT
CAS No:
140187-25-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes.
    Jane et al.
    J.Med.Chem., 1997;40:3645
  2. Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine.
    Patneau et al.
    J.Neurosci., 1992;12:595
  3. Kainate receptors exhibit differential sensitivities to (S)-5-iodowillardiine.
    Swanson et al.
    Mol.Pharmacol., 1998;53:942
  4. Willardiines differentiate agonist binding sites for kainate-versus AMPA-preferring glutamate receptors in DRG and hippocampal neurones.
    Wong et al.
    J.Neurosci., 1994;14:3881
  5. Depolarising effects of certain derivatives of (S) willardiine upon in vitro neonatal rat dorsal roots.
    Thompson et al.
    Br.J.Pharmacol., 1996;117:331P

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Citations for (S)-(-)-5-Iodowillardiine

The citations listed below are publications that use Tocris products. Selected citations for (S)-(-)-5-Iodowillardiine include:

2 Citations: Showing 1 - 2

  1. Subunit-selective iGluR antagonists can potentiate heteromeric receptor responses by blocking desensitization.
    Authors: Pollok and Reiner
    Proc Natl Acad Sci U S A  2020;117:25851
  2. Neuroprotective effect of inhaled nitric oxide on excitotoxic-induced brain damage in neonatal rat.
    Authors: Pansiot Et al.
    Proc Natl Acad Sci U S A  2010;5:e10916

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