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(S)-PFI 2 hydrochloride

Catalog #: 5400
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(S)-PFI 2 hydrochloride | CAS No. 1627607-88-8 | Lysine Methyltransferase Inhibitors
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Description: Negative control of (R)-PFI 2 hydrochloride (Cat. No. 4892)

Chemical Name: 8-Fluoro-1,2,3,4-tetrahydro-N-[(1S)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide hydrochloride

Purity: ≥97%

Product Details
Citations (1)
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Biological Activity

(S)-PFI 2 hydrochloride is a negative control of (R)-PFI 2 hydrochloride. Exhibits 500-fold lower activity in a SETD7 enzymatic assay (IC50 = 1 μM) compared to the active enantiomer.

Active Analog also available.

Technical Data

M.Wt:
535.98
Formula:
C23H25F4N3O3S.HCl
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
1627607-88-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the (R)-PFI 2 probe summary on the SGC website.
Other Product-Specific Information:

Background References

  1. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.
    Barsyte-Lovejoy et al.
    Proc.Natl.Acad.Sci.U S A, 2014;111:12853

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Citation for (S)-PFI 2 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for (S)-PFI 2 hydrochloride include:

1 Citation: Showing 1 - 1

  1. Inhibition of methyltransferase Setd7 allows in vitro expansion of myogenic stem cells with improved therapetic potential.
    Authors: Judson Et al.
    Cell Stem Cell  2018;22:177

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