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(S)-(+)-Rolipram

Catalog #: 1350
4 Citations Datasheet / COA / SDS

Discontinued Product

1350 has been discontinued.
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(S)-(+)-Rolipram | CAS No. 85416-73-5 | Phosphodiesterase Inhibitors
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Description: PDE4 inhibitor. Less active enantiomer of rolipram (Cat. No. 0905)

Chemical Name: (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one

Purity: ≥99%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Less active enantiomer of the PDE4 inhibitor Rolipram.

Racemate and R-enantiomer also available.

Technical Data

M.Wt:
275.35
Formula:
C16H21NO3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
85416-73-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach-Mansky R, Sacks D, Germain R, Kastner D, Chae J
    Nature, 2012;492(7427):123-7.
  3. Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains.
    Ohsawa et al.
    Jpn.J.Pharmacol., 1998;77:147
  4. Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells.
    Owens et al.
    Biochem.J., 1997;326:53
  5. Stereospecific binding of the antidepressant rolipram to brain protein structures.
    Schneider et al.
    Eur.J.Pharmacol., 1986;127:105

Product Datasheets

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Citations for (S)-(+)-Rolipram

The citations listed below are publications that use Tocris products. Selected citations for (S)-(+)-Rolipram include:

4 Citations: Showing 1 - 4

  1. Annexin A1 mediates hydrogen sulfide properties in the control of inflammation.
    Authors: Brancaleone Et al.
    J Pharmacol Exp Ther  2014;351:96
  2. Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model.
    Authors: Boomkamp Et al.
    J Biol Chem  2014;171:2385
  3. Lipidic nanocapsule drug delivery: neuronal protection for cochlear implant optimization.
    Authors: Meyer Et al.
    Int J Nanomedicine  2012;7:2449
  4. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature  2012;492:123

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