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(S)-(-)-Sulpiride

Catalog #: 0895
21 Citations Datasheet / COA / SDS
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0895/100
(S)-(-)-Sulpiride | CAS No. 23672-07-3 | Non-selective Dopamine Receptor Antagonists
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Description: Standard selective D2-like antagonist

Chemical Name: (S)-(-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide

Purity: ≥99%

Product Details
Citations (21)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

(S)-(-)-Sulpiride is an active enantiomer. Selective D2-like dopamine antagonist (Ki values are ~ 0.015, ~ 0.013, 1, ~ 45 and ~ 77 μM at D2, D3, D4, D1 and D5 receptors respectively).

Racemate also available.

Technical Data

M.Wt:
341.42
Formula:
C15H23N3O4S
Solubility:
Soluble to 10 mM in ethanol with gentle warming and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
23672-07-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. DA receptor pharmacology.
    Seeman and Van Tol
    Trends Pharmacol.Sci., 1994;15:264
  3. DA D4 receptors bind inactive (+)-aporphines, suggesting neuroleptic role. Sulpiride not stereoselective.
    Seeman and Van Tol
    Eur.J.Pharmacol., 1993;233:173

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Citations for (S)-(-)-Sulpiride

The citations listed below are publications that use Tocris products. Selected citations for (S)-(-)-Sulpiride include:

21 Citations: Showing 1 - 10

  1. A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors.
    Authors: Pedersen Et al.
    J Biol Chem  2021;296:100503
  2. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner.
    Authors: Dorst Et al.
    Nat Commun  2020;11:5113
  3. Selective blockade of spinal D2DR by levo-corydalmine attenuates MOR tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner.
    Authors: Dai Et al.
    Exp Mol Med  2018;50:148
  4. The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism.
    Authors: Beas Et al.
    Nat Neurosci  2018;21:963
  5. Retroactive modulation of spike timing-dependent plasticity by DA.
    Authors: Brzosko Et al.
    Elife  2015;4
  6. Spinal DArgic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism.
    Authors: Kim Et al.
    J Neurophysiol  2015;35:6307
  7. Agonist and antagonist effects of aripipr. on D2-like receptors controlling rat brain DA synthesis depend on the DArgic tone.
    Authors: Ma Et al.
    Int J Neuropsychopharmacol  2015;18
  8. Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens.
    Authors: Shin Et al.
    J Clin Invest  2015;112:8124
  9. Effects of DA D2-Like Receptor Antagonists on Light Responses of Ganglion Cells in Wild-Type and P23H Rat Retinas.
    Authors: Jensen
    PLoS One  2015;10:e0146154
  10. Phasic DA release drives rapid activation of striatal D2-receptors.
    Authors: Marcott Et al.
    Neuron  2014;84:164
  11. A leptin-mediated central mechanism in analgesia-enhanced opioid reward in rats.
    Authors: Lim Et al.
    J Neurosci  2014;34:9779
  12. DArgic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K+, and T-type Ca2+ channels.
    Authors: Cilz Et al.
    Cereb Cortex  2014;24:3195
  13. Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra DA neurons.
    Authors: Dragicevic Et al.
    J Neurosci  2014;137:2287
  14. Gene-environment interactions affect long-term depression (LTD) through changes in DA receptor affinity in Snap25 deficient mice.
    Authors: Baca Et al.
    Brain Res  2013;1532:85
  15. Neurite outgrowth mediated by the heat shock protein Hsp90α: a novel target for the antipsychotic drug aripipr.
    Authors: Ishima Et al.
    Transl Psychiatry  2012;2:e170
  16. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
    Authors: Kurita Et al.
    Nat Neurosci  2012;15:1245
  17. DA neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection.
    Authors: Chuhma Et al.
    Neuroscience  2009;164:1068
  18. Co-transmission of DA and GABA in periglomerular cells.
    Authors: Maher and Westbrook
    Proc Natl Acad Sci U S A  2008;99:1559
  19. Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.
    Authors: Costa Et al.
    J Neurosci  2008;28:8040
  20. DArgic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons.
    Authors: Wang Et al.
    Neuron  2006;50:443
  21. Inhibition of ATP-sensitive potassium channels by halope.
    Authors: Yang Et al.
    Br J Pharmacol  2004;143:960

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