(S)-WAY 100135 dihydrochloride
Chemical Name: (S)-N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide dihydrochloride
Purity: ≥99%
Biological Activity
(S)-WAY 100135 dihydrochloride is a potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). Selective over 5-HT1B, 1C, 2,α1, α2 and D2 receptors (IC50 > 1000 nM). Centrally active on systemic administration.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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(S)-N-tert-Butyl-3(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.
Cliffe et al.
J.Med.Chem., 1993;36:1509 -
WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.
Fletcher et al.
Eur.J.Pharmacol., 1993;237:283 -
Silent 5-HT1A receptor antagonists: utility as research tools and therapeutic agents.
Fletcher et al.
Trends Pharmacol.Sci., 1993;14:41 -
Anxiolytic-like effect of (S)-WAY 100135, a 5-HT1A receptor antagonist, in the murine elevated plus-maze test.
Rodgers and Cole
Eur.J.Pharmacol., 1994;261:321
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Citations for (S)-WAY 100135 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for (S)-WAY 100135 dihydrochloride include:
7 Citations: Showing 1 - 7
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Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival.
Authors: Saxena Et al.
Neuron 2013;80:80
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Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT?a receptor antagonist.
Authors: Pandya and Yakel
Neuropharmacology 2013;70:35
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The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity.
Authors: Borroto-Escuela Et al.
J Neurosci 2012;32:6295
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5-HT1A receptor-responsive pedunculopontine tegmental neurons suppress REM sleep and respiratory motor activity.
Authors: Grace Et al.
J Neurosci 2012;32:1622
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Multiple neural oscillators and muscle feedback are required for the intestinal fed state motor program.
Authors: Chambers Et al.
PLoS One 2011;6:e19597
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5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum.
Authors: Foong Et al.
J Neurosci 2010;298:G384
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Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs.
Authors: Hampson Et al.
Diabetologia 2007;50:1743
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