SAR 216471 hydrochloride

Name: SAR 216471 hydrochloride
Brand: Tocris Bioscience
SKU: 5650
Price: 244 USD

Catalog #: 5650
1 Citation Datasheet / COA / SDS

Discontinued Product

5650 has been discontinued.

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SAR 216471 hydrochloride | CAS No. 1279829-64-9 | P2Y Receptor Antagonists

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Description: Potent P2Y12 antagonist; orally available

Chemical Name: 5-Chloro-N-[6-[5-methyl-4-(1-oxobutyl)-1H-pyrazol-1-yl]-3-pyridazinyl]-1-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride

Purity: ≥98%

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Product Details

Citations (1)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SAR 216471 hydrochloride is a potent P2Y₁₂ antagonist (IC₅₀ = 17 nM). Displays antiplatelet and antithrombotic activity in vivo. Orally available.

Technical Data

M.Wt:

599.51

Formula:

C₂₈H₃₁ClN₈O₃.HCl

Solubility:

Soluble to 20 mM in DMSO with gentle warming

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

1279829-64-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist.
Boldron et al.
J.Med.Chem., 2014;57:7293

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M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for SAR 216471 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SAR 216471 hydrochloride include:

1 Citation: Showing 1 - 1

Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors.
Authors: Liu Et al.
Sci Rep 2018;8(1):11380

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