Home / TRPC Channel Blockers / SAR 7334

SAR 7334

Catalog #: 5831
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5831/5
SAR 7334 | CAS No. 1333207-63-8 | TRPC Channel Blockers
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Description: Potent TRPC6 inhibitor

Chemical Name: 4-[[(1R,2R)-2-[(3R)-3-Amino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile dihydrochloride

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SAR 7334 is a potent TRPC6 inhibitor (IC50 values are 9.5, 226 and 282 nM for TRPC6, TRPC7 and TRPC3-mediated Ca2+ influx). Exhibits no significant activity at TRPC4 and TRPC5 channels. Suppresses TRPC6-dependent acute hypoxic pulmonary vasoconstriction (HPV) in the isolated perfused mouse lung. Orally bioavailable.

Technical Data

M.Wt:
440.79
Formula:
C21H22ClN3O.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1333207-63-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SAR 7334

The citations listed below are publications that use Tocris products. Selected citations for SAR 7334 include:

4 Citations: Showing 1 - 4

  1. Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels.
    Authors: Gertjan Et al.
    PLoS Biol  2021;19:e3001070
  2. Sites of Circadian Clock Neuron Plasticity Mediate Sensory Integration and Entrainment.
    Authors: Orie T Et al.
    Curr Biol  2020;30:2225-2237.e5
  3. Role of opioid signaling in kidney damage during the development of salt-induced hypertension.
    Authors: Vladislav Et al.
    Life Sci Alliance  2020;3
  4. The activity of transient receptor potential channel C-6 modulates the differentiation of fat cells.
    Authors: Xiaoqiang Et al.
    FASEB J  2019;33:6526-6538

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