SB 216641 hydrochloride

Catalog #: 1242
5 Citations Datasheet / COA / SDS

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SB 216641 hydrochloride | CAS No. 193611-67-5 | 5-HT1B Receptor Antagonists

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Description: Selective h5-HT1B antagonist

Chemical Name: N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride

Purity: ≥98%

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Product Details

Citations (5)

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

SB 216641 hydrochloride is a selective h5-HT_1B antagonist with approximately 25-fold selectivity over h5-HT_1D and little or no affinity for a range of other receptor types.

Technical Data

M.Wt:

523.03

Formula:

C₂₈H₃₀N₄O₄.HCl

Solubility:

Soluble to 50 mM in water

Purity:

≥98%

Storage:

Store at RT

CAS No:

193611-67-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold with the permission of GlaxoSmithKline

Background References

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
Stimulation of 5-HT_1B receptors causes hypothermia in the guinea pig.
Hagan et al.
Eur.J.Pharmacol., 1997;331:169
SB-216641 and BRL-15572 - compounds to pharmacologically discriminate h5-HT_1B and h5-HT_1D receptors.
Price et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1997;356:312
Effects of selective h5-HT_1B (SB-216641) and 5-HT_1D (BRL-15572) receptor ligands on guinea pig and human 5-HT auto- and heteroreceptors.
Schlicker et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1997;356:321

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Citations for SB 216641 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SB 216641 hydrochloride include:

5 Citations: Showing 1 - 5

Amygdala-hippocampal phospholipase D (PLD) signaling as novel mechanism of cocaine-environment maladaptive conditioned responses.
Authors: Krishnan
Int.J.Neuropsychopharmacol. 2016;19:1
Expression of serotonin receptors in human hepatocellular cancer.
Authors: Soll Et al.
Clin Cancer Res 2012;18:5902
Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.
Authors: Murray Et al.
J Neurophysiol 2011;106:925
Endogenous extracellular serotonin modulates the spinal locomotor network of the neonatal mouse.
Authors: Dunbar Et al.
J Physiol 2010;588:139
Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses.
Authors: Watakabe Et al.
J Biol Chem 2009;19:1915

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