SB 224289 hydrochloride

Catalog #: 1221
8 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
1221/10
1221/50

SB 224289 hydrochloride | CAS No. 180084-26-8 | 5-HT1B Receptor Antagonists

1 Image

Description: Selective 5-HT1B antagonist

Chemical Name: 1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine hydrochloride

Purity: ≥95%

View All Products for 5-HT1B Receptor Antagonists

Product Details

Citations (8)

Supplemental Products

Reviews

Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

SB 224289 hydrochloride is a selective 5-HT_1B receptor antagonist (pK_i = 8.2). Displays > 60-fold selectivity over 5-HT_1D, 5-HT_1A, 5-HT_1E, 5-HT_1F, 5-HT_2A and 5-HT_2C receptors in radioligand binding and functional assays. Centrally active following oral administration in vivo.

Technical Data

M.Wt:

557.09

Formula:

C₃₂H₃₂N₄O₃.HCl

Solubility:

Soluble to 10 mM in DMSO with gentle warming

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

180084-26-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold with the permission of GlaxoSmithKline

Background References

Stimulation of 5-HT_1B receptors causes hypothermia in the guinea-pig.
Hagan et al.
Eur.J.Pharmacol., 1997;331:169
SB-224289 - a novel selective (human) 5-HT_1B receptor antagonist with negative intrinsic activity.
Selkirk et al.
Br.J.Pharmacol., 1998;125:202
Differential effects of 5-HT_1B/1D receptor antagonists in dorsal and median raphe innervated brain regions.
Roberts et al.
Eur.J.Pharmacol., 1998;346:175
The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine (SB-224289) potently blocks terminal 5-HT
Gaster et al.
J.Med.Chem., 1998;41:1218

Product Datasheets

COA view current batch

Or select another batch:

View Batch

SDS

Reconstitution Calculator

Molarity Calculator

Reconstitution Calculator

Molarity Calculator

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for SB 224289 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SB 224289 hydrochloride include:

8 Citations: Showing 1 - 8

Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells.
Authors: Hirono
Neuropharmacology 2017;118:79
SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A.
Authors: Cassilly Et al.
Mol Ther 2016;11:e0154932
Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres.
Authors: Baillie Et al.
PLoS One 2012;63:362
Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension.
Authors: Morecroft Et al.
Neuron 2012;20:1516
Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.
Authors: Murray Et al.
J Neurophysiol 2011;106:925
Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs.
Authors: Hampson Et al.
Diabetologia 2007;50:1743
Serotonin reciprocally regulates melanocortin neurons to modulate food intake.
Authors: Heisler Et al.
J Neurosci 2006;51:239
The role of serotonin (5-hydroxytryptamine_1A and _1B) receptors in prostate cancer cell proliferation.
Authors: Siddiqui Et al.
J Urol 2006;176:1648

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for SB 224289 hydrochloride

There are currently no reviews for this product. Be the first to review SB 224289 hydrochloride and earn rewards!

Have you used SB 224289 hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.