SB 258585 hydrochloride
Chemical Name: 4-Iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]benzenesulfonamide hydrochloride
Purity: ≥98%
Biological Activity
SB 258585 hydrochloride is a potent and selective 5-HT6 receptor antagonist (pKi = 8.6); displays > 160-fold selectivity over other 5-HT receptor subtypes.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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5-Chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesulfonamide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist.
Bromidge et al.
J.Med.Chem., 1999;42:202 -
5-HT6 receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with [125I]SB-258585.
East et al.
Synapse, 2002;45:191 -
Characterization of [125I]-SB-258585 binding to human recombinant and native 5-HT6 receptors in rat, pig and human brain tissue.
Hirst et al.
Br.J.Pharmacol., 2000;130:1597
Product Datasheets
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Citations for SB 258585 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for SB 258585 hydrochloride include:
3 Citations: Showing 1 - 3
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Activation and blockade of basolateral amygdala 5-HT6 receptor produce anxiolytic-like behaviors in an experimental model of Parkinson's disease.
Authors: Sun Et al.
Neuropharmacology 2018;137:275
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Peripheral serotonin-mediated system suppresses bone development and regeneration via serotonin 6 G-protein-coupled receptor.
Authors: Yun Et al.
Scientific Reports 2016;6:30985
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Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs.
Authors: Hampson Et al.
Diabetologia 2007;50:1743
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