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SB 265610

Catalog #: 2724
8 Citations Datasheet / COA / SDS
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2724/1
SB 265610 | CAS No. 211096-49-0 | Chemokine Receptor Antagonists
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Description: Potent CXCR2 antagonist

Chemical Name: N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea

Purity: ≥98%

Product Details
Citations (8)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

SB 265610 is a potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca2+ mobilization (IC50 values are 3.4 and 6800 nM respectively). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo.

Technical Data

M.Wt:
357.16
Formula:
C14H9BrN6O
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
211096-49-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

Background References

  1. Regulation of CXCR2 expression and function by a disintegrin and metalloprotease-17 (ADAM17).
    Mishra H, Long C, Bahaie N, Walcheck B
    J Leukoc Biol, 2015;97(3):447-54.
  2. CXCR2 and its related ligands play a novel role in supporting the pluripotency and proliferation of human pluripotent stem cells.
    Jung J, Lee S, Kim J, Lee S, Sung H, An J, Park Y, Kim B
    Stem Cells Dev, 2015;24(8):948-61.
  3. Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation
    M Taki, K Abiko, T Baba, J Hamanishi, K Yamaguchi, R Murakami, K Yamanoi, N Horikawa, Y Hosoe, E Nakamura, A Sugiyama, M Mandai, I Konishi, N Matsumura
    Nat Commun, 2018;9(1):1685.
  4. Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats.
    Auten et al.
    J.Pharmacol.Exp.Ther., 2001;299:90
  5. Impaired healing of nitrogen mustard wounds in CXCR2 null mice.
    Milatovic et al.
    Wound Repair Regen., 2003;11:213

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Citations for SB 265610

The citations listed below are publications that use Tocris products. Selected citations for SB 265610 include:

8 Citations: Showing 1 - 8

  1. Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues.
    Authors: He Et al.
    Immunity  2018;49:1175
  2. CXCR2 Inhibition in Human Pluripotent Stem Cells Induces Predominant Differentiation to Mesoderm and Endoderm Through Repression of mTOR, β-Catenin, and hTERT Activities.
    Authors: Jung Et al.
    Stem Cells Dev  2016;25:1006
  3. Immune Antibodies and Helminth Products Drive CXCR2-Dependent Macrophage-Myofibroblast Crosstalk to Promote Intestinal Repair.
    Authors: Bieren Et al.
    PLoS Pathog  2015;11:e1004778
  4. A novel phenylcyclohex-1-enecarbothioamide derivative inhibits CXCL8-mediated chemotaxis through selective regulation of CXCR2-mediated signalling.
    Authors: Ha Et al.
    Br J Pharmacol  2014;171:1551
  5. Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor.
    Authors: Toh Et al.
    PLoS Biol  2011;9:e1001162
  6. Mesenchymal stem cells promote mammary cancer cell migration in vitro via the CXCR2 receptor.
    Authors: Halpern Et al.
    Cancer Lett  2011;308:91
  7. Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function.
    Authors: Burton Et al.
    Blood  2011;117:333
  8. IL-4 activates equine neutrophils and induces a mixed inflammatory cytokine expression profile with enhanced neutrophil chemotactic mediator release ex vivo.
    Authors: Lavoie-Lamoureux Et al.
    Am J Physiol Lung Cell Mol Physiol  2010;299:L472

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