SB 3CT
Chemical Name: 2-[[(4-Phenoxyphenyl)sulfonyl]methyl]thiirane
Purity: ≥98%
Biological Activity
SB 3CT is a selective high affinity MMP2 inhibitor (Ki = 28 nM); also inhibits MMP9 (Ki = 400 nM). Active in vivo, neuroprotective and blood-brain barrier permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia.
Gu et al.
J.Neurosci., 2005;25:6401 -
X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme.
Kleifeld et al.
J.Biol.Chem., 2001;18:17125 -
Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier.
Gooyit et al.
ACS Chem.Neurosci., 2012;3:730
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Citation for SB 3CT
The citations listed below are publications that use Tocris products. Selected citations for SB 3CT include:
1 Citation: Showing 1 - 1
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Role of matrix metalloproteinase-9 in neurodevelopmental deficits and experience-dependent plasticity in Xenopus laevis.
Authors: Lin-Chien Et al.
Elife 2021;10
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