SB 4
Chemical Name: 2-[[(4-Bromophenyl)methyl]thio]benzoxazole
Purity: ≥99%
Biological Activity
SB 4 is a potent BMP4 agonist (EC50 = 74 nM). Activates canonical BMP signaling and increases SMAD-1/5/9 phosphorylation, with no effect on p-SMAD-2, p-SMAD-3 or p-TAK1. Bypasses noggin-induced inhibition of type I BMP receptors. When used in combination, SB 4 enhances BMP4 signaling and embryonic stem cell differentiation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds.
Bradford et al.
J.Biol.Chem., 2019;294:3125
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Citation for SB 4
The citations listed below are publications that use Tocris products. Selected citations for SB 4 include:
1 Citation: Showing 1 - 1
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A comparison between BMP4 and SB4 in inducing germ line gene expression pattern during embryonic stem cells differentiation.
Authors: Hayaei Tehrani Et al.
Differentiation 2022;123:9
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