SCH 202676 hydrobromide
Chemical Name: N-(2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine hydrobromide
Purity: ≥98%
Biological Activity
SCH 202676 hydrobromide is a sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC50 values are 0.1-1.8 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors.
Fawzi et al.
Mol.Pharmacol., 2001;59:30 -
Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors.
Gao et al.
Life Sci., 2004;74:3173 -
The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms.
Lewandowicz et al.
Br.J.Pharmacol., 2006;147:422
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Citation for SCH 202676 hydrobromide
The citations listed below are publications that use Tocris products. Selected citations for SCH 202676 hydrobromide include:
1 Citation: Showing 1 - 1
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Both Type I and Type II Interferons Can Activate Antitumor M1 Macrophages When Combined With TLR Stimulation.
Authors: M?ller Et al.
Front Immunol 2018;9:2520
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Used as GPCR inhibitor for Glucagon treatment in mouse primary hepatocytes. As shown in the picture, from left to right, 1st sample is untreated, 2nd sample was treated with Glucagon, 3rd sample was pre-treated with this chemical plus glucagon, seems pretty effective for inhibiting glucagon stimulated p-CREB activation. however this chemical is not very stable, seems to loose effectiveness after short storage. Overall is happy with this product.
