SCH 221510
Chemical Name: 3-Endo-8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol
Purity: ≥99%
Biological Activity
SCH 221510 is a potent and selective nociceptin opioid receptor (NOP) agonist (EC50 values are 12, 693, 683 and 8071 nM, and Ki values are 0.3, 65, 131 and 2854 nM at NOP, μ-, κ- and δ-opioid receptors respectively). Exhibits anxiolytic-like activity at doses that have no effect on overt behaviors such as locomotion in vivo. Orally active.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510).
Varty et al.
J.Pharmacol.Exp.Ther., 2008;326:672 -
The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential.
Lambert
Nat.Rev.Drug Discov., 2008;7:694 -
Identification of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the management of cough and anxiety.
Yang et al.
Bioorg.Med.Chem.Lett., 2009;19:2482
Product Datasheets
Citation for SCH 221510
The citations listed below are publications that use Tocris products. Selected citations for SCH 221510 include:
1 Citation: Showing 1 - 1
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ORL1 activation mediates a novel ORL1 receptor agonist SCH221510 analgesia in neuropathic pain in rats.
Authors: Wu & Liu
J Mol Neurosci 2018;66:10
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