SCH 39166 hydrobromide
Chemical Name: (6aS-trans)-11-Chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b]azepin-12-ol hydrobromide
Purity: ≥99%
Biological Activity
SCH 39166 hydrobromide is a high affinity dopamine D1/D5 receptor antagonist; displays Ki values of 1.2, 2, 980, 5520, 80 and 731 nM for binding to D1, D5, D2, D4, 5-HT and α2a receptors, respectively.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A leptin-mediated central mechanism in analgesia-enhanced opioid reward in rats.
Lim G, Kim H, McCabe M, Chou C, Wang S, Chen L, Marota J, Blood A, Breiter H, Mao J
J Neurosci, 2014;34(29):9779-88. -
DA D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists.
Wu et al.
J.Med.Chem., 2005;48:680 -
A comparison of the effects of the D1 receptor antagonists SCH 23390 and SCH 39166 on suppression of feeding behaviour by the D1 agonist SKF38393.
Terry and Katz
Psychopharmacology, 1994;113:328 -
In vivo binding of SCH 39166: a D-1 selective antagonist.
McQuade et al.
J.Pharmacol.Exp.Ther., 1991;257:42
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Citations for SCH 39166 hydrobromide
The citations listed below are publications that use Tocris products. Selected citations for SCH 39166 hydrobromide include:
6 Citations: Showing 1 - 6
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A leptin-mediated central mechanism in analgesia-enhanced opioid reward in rats.
Authors: Lim Et al.
J Neurosci 2014;34:9779
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Attenuated DArgic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes.
Authors: Zheng Et al.
Nat Commun 2014;306:R138
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RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes.
Authors: Fleischmann Et al.
Mol Cancer 2014;13:27
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The DA D1 receptor is expressed and facilitates relaxation in airway smooth muscle.
Authors: Mizuta Et al.
Am J Physiol Regul Integr Comp Physiol 2013;14:89
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Differential effects of selective adenosine antagonists on the effort-related impairments induced by DA D1 and D2 antagonism.
Authors: Nunes Et al.
Neuroscience 2010;170:268
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Cannabinoid CB1 antagonists and DA antagonists produce different effects on a task involving response allocation and effort-related choice in food-seeking behavior.
Authors: Sink Et al.
Psychopharmacology (Berl) 2008;196:565
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