Scopolamine hydrobromide

Catalog #: 1414
17 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
1414/1G

Scopolamine hydrobromide | CAS No. 114-49-8 | Non-selective mAChR Antagonists

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Description: Non-selective muscarinic antagonist

Chemical Name: (α,S)-α-(Hydroxymethyl)benzeneacetic acid (1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester hydrobromide

Purity: ≥99%

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Product Details

Citations (17)

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Biological Activity

Scopolamine hydrobromide is a non-selective muscarinic antagonist. Widely used clinically to treat motion sickness.

Technical Data

M.Wt:

384.27

Formula:

C₁₇H₂₁NO₄.HBr

Solubility:

Soluble to 100 mM in water and to 50 mM in DMSO

Purity:

≥99%

Storage:

Store at RT

CAS No:

114-49-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Role of Muscarinic Acetylcholine Receptors in Serial Feature-Positive Discrimination Task during Eyeblink Conditioning in Mice.
Rahman M, Tanaka N, Usui K, Kawahara S
PLoS ONE, 2016;11(1):e0147572.
Effects of scopol. in comparison with apomor. and phencyclidine on prepulse inhibition in rats.
Jones and Shannon
Eur.J.Pharmacol., 2000;391:105
Cerebral blood flow responses to somatosensory stimulation are unaffected by scopol. in unanesthetized rat.
Nakao et al.
J.Pharmacol.Exp.Ther., 1999;290:929
An examination of central actions characteristic of scopolamine: comparison of central and peripheral activity in scopolamine, atr. and some synthetic basic esters.
Parkes
Psychopharmacologia, 1965;7:1

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Scopolamine hydrobromide

The citations listed below are publications that use Tocris products. Selected citations for Scopolamine hydrobromide include:

17 Citations: Showing 1 - 10

Astroglia in lateral habenula is essential for antidepressant efficacy of light.
Authors: Delcourte Et al.
BioRXiv - not yet peer reviewed 2020;
Cognitive enhancer effects of low Mem. doses are facilitated by an alpha7 nicotinic acetylcholine receptor agonist in scopolamine-induced amnesia in rats.
Authors: Bali Et al.
Front Pharmacol 2019;10:73
DA Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of DA and Glutamate.
Authors: Cai & Ford
Cell Rep 2018;25:3148
(2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray.
Authors: Chou Et al.
Neuropharmacology 2018;139:1
The brain is required for normal muscle and nerve patterning during early Xenopus development.
Authors: Herrera-Rincon Et al.
Nat Commun 2017;8:587
Impact of Altered Cholinergic Tones on the Neurovascular Coupling Response to Whisker Stimulation.
Authors: Lecrux Et al.
J Neurosci 2017;37:1518
Nicotinic and opioid receptor regulation of striatal DA D2-receptor mediated transmission
Authors: Mamaligas Et al.
Scientific Reports 2016;6:37834
σ1 receptor ligands control a switch between passive and active threat responses.
Authors: Rennekamp Et al.
Nat Chem Biol 2016;12:552
Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability.
Authors: Parent Et al.
Proc Natl Acad Sci U S A 2015;9:284
Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
Authors: Saunders Et al.
Front Behav Neurosci 2015;4

Differential effects of α7 nicotinic receptor agonist PHA-543613 on spatial memory performance of rats in two distinct pharmacological dementia models.
Authors: Bali Et al.
Brain Behav Res 2015;278:404

Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens.
Authors: Shin Et al.
J Neurosci 2015;112:8124

Phasic DA release drives rapid activation of striatal D2-receptors.
Authors: Marcott Et al.
Neuron 2014;84:164

DA neurons control striatal cholinergic neurons via regionally heterogeneous DA and glutamate signaling.
Authors: Chuhma Et al.
Elife 2014;81:901

Prior pathology in the basal forebrain cholinergic system predisposes to inflammation-induced working memory deficits: reconciling inflammatory and cholinergic hypotheses of delirium.
Authors: Field Et al.
J Neurosci 2012;32:6288

Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum.
Authors: Higley Et al.
PLoS One 2011;6:e19155

DA neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection.
Authors: Chuhma Et al.
Neuroscience 2009;164:1068

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