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SDZ 21009

Catalog #: 1516 Datasheet / COA / SDS

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SDZ 21009 | CAS No. 39731-05-0 | Non-selective Adrenergic beta Receptor Antagonists
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Description: β-adrenoceptor antagonist; also 5-HT1A and 5-HT1B antagonist

Chemical Name: 4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-1H-indole-2-carboxylic acid, 1-methylethyl ester

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Biological Activity

SDZ 21009 is an β-adrenoceptor and 5-HT1A/1B receptor antagonist. pKB/pA2 values are 8.3 and 8.0 for 5-HT1A and 5-HT1B receptors respectively. Centrally active following systemic administration in vivo.

Technical Data

M.Wt:
348.44
Formula:
C19H28N2O4
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Storage:
Store at RT
CAS No:
39731-05-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Evidence for the involvement of 5-HT1A receptors in the anticonflict effect of ipsapirone in rats.
    Chojnacka-Wojcik and Przegalinski
    Neuropharmacology, 1991;30:703
  2. VII International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin).
    Hoyer et al.
    Pharmacol.Rev., 1994;46:157
  3. Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites.
    Engel et al.
    Naunyn-Schmied.Arch.Pharmacol., 1986;332:1

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