SDZ 220-581
Chemical Name: (S)-α-Amino-2'-chloro-5-(phosphonomethyl)[1,1'-biphenyl]-3-propanoic acid
Purity: ≥98%
Biological Activity
SDZ 220-581 is a competitive NMDA receptor antagonist (pKi = 7.7). Centrally active following oral administration (ED50 < 3.2 mg/kg for protection against MES-induced seizures).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Disruption of prepulse inhibition and increases in locomotor activity by competitive N-MthD.-aspartate receptor antagonists in rats.
Bakshi et al.
J.Pharmacol.Exp.Ther., 1999;288:643 -
Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-MthD.-aspartate receptor antagonists - I. Pharmacological characterization in vitro.
Urwyler et al.
Neuropharmacology, 1996;35:643 -
Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-MthD.-aspartate receptor antagonists - II. Pharmacological characterization in vivo.
Urwyler et al.
Neuropharmacology, 1996;35:655
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