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SDZ WAG 994

Catalog #: 2465 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2465/10
SDZ WAG 994 | CAS No. 130714-47-5 | Adenosine A1 Receptor Agonists
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Description: Potent and selective A1 agonist

Chemical Name: N-Cyclohexyl-2'-O-methyladenosine

Purity: ≥99%

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Biological Activity

SDZ WAG 994 is a potent and selective A1 adenosine receptor agonist (Ki values are 23, > 10000 and 25000 nM for A1, A2A and A2B receptors respectively). Causes a sustained fall in blood pressure and heart rate in spontaneous hypertensive rats and inhibits adenosine deaminase-stimulated lipolysis in rat adipocytes (Ki = 8 nM).

Technical Data

M.Wt:
363.41
Formula:
C17H25N5O4
Solubility:
Soluble to 100 mM in 1.1eq. NaOH and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
130714-47-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Adenosine receptors as therapeutic targets.
    Jacobson and Gao
    Nat.Rev.Drug Discov., 2006;5:247
  2. Hypoglycemic and hypotensive effects of 6-cyclohexyl-2'-O-methyl-adenosine, an adenosine A1 receptor agonist, in spontaneous hypertensive rat complicated with hyperglycemia.
    Ishikawa et al.
    Diabetes Res.Clin.Pract., 1998;39:3
  3. General pharmacology of SDZ WAG 994, a potent selective and orally active adenosine A1 receptor agonist.
    Wagner et al.
    Drug Dev.Res., 1995;34:276

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