Senktide
Purity: ≥95%
Biological Activity
Senktide is a NK3 tachykinin receptor agonist. Causes direct excitation of dopamine neurons; enhances dopaminergic function. Induces locomotor activity.Technical Data
(Modifications: Asp-1 = Succinyl-Asp, Phe-3 = Me-Phe, Met-6 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Evidence of a role for kisspeptin and neurokinin B in puberty of female sheep.
Endocrinology, 2012;153(6):2756-65. -
The selective NK receptor agonist senktide excites a subpopulation of DA-sensitive neurones in the rat substantia nigra pars compacta in vitro.
Keegan et al.
Br.J.Pharmacol., 1992;105:3 -
The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils.
Nordquist et al.
Eur.J.Pharmacol., 2008;600:87 -
Characterization of NK-3 binding sites in rat and guinea-pig cortical membranes by the selective ligand [3H]senktide.
Renzetti et al.
Neuropeptides, 1991;18:107
Product Datasheets
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Citations for Senktide
The citations listed below are publications that use Tocris products. Selected citations for Senktide include:
8 Citations: Showing 1 - 8
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NKB signaling in the posterodorsal medial amygdala stimulates Gn release in a kisspeptin-independent manner in female mice.
Authors: Fergani Et al.
Elife 2018;7
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The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress.
Authors: Zelikowsky Et al.
Cell 2018;173:1265
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Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity.
Authors: León Et al.
Endocrinology 2016;6:19206
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The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction.
Authors: Navarro Et al.
Nat Commun 2015;156:627
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Neurokinin B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons.
Authors: Glidewell-Kenney Et al.
Mol Endocrinol 2013;27:437
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GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats.
Authors: Grachev Et al.
Cereb Cortex 2012;7:e44344
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Cortical sources of CRF, NKB, and CCK and their effects on pyramidal cells in the neocortex.
Authors: Gallopin Et al.
J Neurosci 2006;16:1440
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Role of neurokinin 3 receptors in supraoptic vasopressin and oxyt. neurons.
Authors: Howe Et al.
Sci Rep 2004;24:10103
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