SET 2
Chemical Name: N-(2-Furanylmethyl)-3-[[4-(methylpropylamino)-6-(trifluoromethyl)-2-pyrimidinyl]thio]propanamide
Purity: ≥98%
Biological Activity
SET 2 is a TRPV2 (transient receptor potential vanilloid type 2) antagonist (IC50 = 0.46 μM). Selective for TRPV2 over TRPV1, TRPV3 and TRPV4 expressed in HEK293 cells. Inhibits lyosphosphatidic acid (LPA)-induced prostate cancer cell migration in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Structure-based discovery of a subtype-selective inhibitor targeting a transient receptor potential vanilloid channel.
Chai et al.
J.Med.Chem., 2019;62:1373
Product Datasheets
Citation for SET 2
The citations listed below are publications that use Tocris products. Selected citations for SET 2 include:
1 Citation: Showing 1 - 1
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The Effect of Cannabis Plant Extracts on Head and Neck Squamous Cell Carcinoma and the Quest for Cannabis-Based Personalized Therapy.
Authors: Yaniv Et al.
Cancers (Basel) 2023;15
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