SGC GAK 1

Catalog #: 6564 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
6564/5
6564/25

SGC GAK 1 | CAS No. 2226517-76-4 | Other Kinase Inhibitors

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Description: High affinity cyclin G associated kinase (GAK) inhibitor

Chemical Name: 6-Bromo-N-(3,4,5-trimethoxyphenyl)-4-quinolinamine

Purity: ≥99%

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Product Details

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

SGC GAK 1 is a high affinity cyclin G associated kinase (GAK) inhibitor (K_d = 1.9 nM). Exhibits >30-fold selectivity for GAK over a panel of other kinases. Inhibits GAK in live cell assays (IC₅₀ = 110 nM).

Technical Data

M.Wt:

389.24

Formula:

C₁₈H₁₇BrN₂O₃

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

≥99%

Storage:

Store at -20°C

CAS No:

2226517-76-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC GAK 1 probe summary on the SGC website.

Background References

SGC-GAK-1: a chemical probe for cyclin G associated kinase (GAK).
Asquith et al.
J.Med.Chem., 2019;62:2830
Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK).
Asquith et al.
Bioorg.Med.Chem.Lett., 2019;29:1727

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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