SHIN 1
Chemical Name: 6-Amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)pyrano[2,3-c]pyrazole-5-carbonitrile
Purity: ≥98%
Biological Activity
SHIN 1 is a potent serine hydroxymethyltransferase (SHMT) inhibitor (IC50 values are 5 and 13 nM at SHMT1 and SHMT2, respectively). Inhibits growth of HCT-116 cells in vitro (IC50 = 870 nM). Unstable in liver microsome assays.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma.
Ducker et al.
Proc.Natl.Acad.Sci.U.S.A., 2017;114:11404
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Citation for SHIN 1
The citations listed below are publications that use Tocris products. Selected citations for SHIN 1 include:
1 Citation: Showing 1 - 1
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SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication.
Authors: Vamsi K Et al.
Nat Commun 2021;12:1676
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