Silodosin
Chemical Name: 2,3-Dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carboxamide
Purity: ≥98%
Biological Activity
Silodosin is a selective α1A adrenoceptor antagonist (Ki = 0.036 nM). Displays >55 fold selectivity for α1A over α1B and α1D. Inhibits norepinephrine-induced [Ca2+]I increase in α1A expressing CHO cells (IC50 = 0.32 nM). Inhibits norepinephrine-induced contraction of isolated human prostate tissue.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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KMD-3213, a novel, potent, alpha 1a-adrenoceptor-selective antagonist: characterization using recombinant human alpha 1-adrenoceptors and native tissues.
Shibata et al.
Mol.Pharmacol., 1995;48:250 -
KMD-3213, a novel alpha1A-adrenoceptor antagonist, potently inhibits the functional alpha1-adrenoceptor in human prostate.
Moriyama et al.
Eur.J.Pharmacol., 1997;331:39
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Citation for Silodosin
The citations listed below are publications that use Tocris products. Selected citations for Silodosin include:
1 Citation: Showing 1 - 1
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A common variant in 11q23.3 associated with hyperlipidemia is mediated by the binding and regulation of GATA4.
Authors: Wen Cheng Et al.
NPJ Genom Med 2022;7:4
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