Simple Plex Discover Mouse/Rat Park7 Assay New

Simple Plex Discover Mouse/Rat Park7 Assay Summary

*The Sample Volume represented is based on the amount of sample incorporated into the reaction after taking into account the assay’s minimum required dilution for a given matrix. Serial dilution may be necessary to achieve some of the final sample volumes represented.

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Background: Park7/DJ-1

Park7, also known as DJ-1, is a cytoplasmic protein that belongs to the ThiJ/Pfp1/DJ-1 superfamily of highly conserved proteins that function as protein chaperones, catalases, proteases and kinases. Park7 is widely expressed in the brain as well as in peripheral tissues. It exists as a homodimer that can be localized in the cytoplasm, nucleus and mitochondria. Park7 is a redox-sensitive protein that has been ascribed various functions including that as a redox sensor and antioxidant protein. Mutations in Park7 are associated with a small percentage of hereditary early onset Parkinson's disease.

Related Research Areas

• Anti-oxidant Molecules
• Parkinson's Disease Related Molecules
• ROS Sensors, Adducts, and Inhibitor Molecules
• Stem Cell Transcription Factor Regulators
• Transcriptional Co-Activators