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SirReal 2

Catalog #: 5457 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5457/10
5457/50
SirReal 2 | CAS No. 709002-46-0 | Class III Histone Deacetylases Inhibitors
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Description: Selective inhibitor of SIRT2

Chemical Name: 2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide

Purity: ≥98%

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Biological Activity

SirReal 2 is a selective SIRT2 inhibitor (IC50 = 140 nM). Has minimal effect on SIRT1 and SIRT3-6. Increases α-tubulin acetylation levels in HeLa cells.

Technical Data

M.Wt:
420.55
Formula:
C22H20N4OS2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
709002-46-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Selective SIRT2 inhibition by ligand-induced rearrangement of the active site.
    Rumpf et al.
    Nat.Commun., 2015;6:6263

Product Datasheets

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