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Sivelestat sodium salt

Catalog #: 3535
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3535/10
3535/50
Sivelestat sodium salt | CAS No. 150374-95-1 | Synthetic Elastase Inhibitors
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Description: Selective leukocyte elastase inhibitor
Alternative Names: ONO-5046

Chemical Name: N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine sodium salt

Purity: ≥98%

Product Details
Citations (6)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Sivelestat sodium salt is a selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-κB activation and LTB4-induced neutrophil transmigration in vitro. Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo.

Technical Data

M.Wt:
456.44
Formula:
C20H21N2NaO7S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
150374-95-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Sivelestat sodium salt

The citations listed below are publications that use Tocris products. Selected citations for Sivelestat sodium salt include:

6 Citations: Showing 1 - 6

  1. Camostat Does Not Inhibit the Proteolytic Activity of Neutrophil Serine Proteases.
    Authors: Marcin Et al.
    Pharmaceuticals (Basel)  2022;15
  2. Neutrophil elastase from myeloid cells promotes TSC2-null tumor growth.
    Authors: Javier Et al.
    Endocr Relat Cancer  2020;27:261-274
  3. Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation.
    Authors: Berg Et al.
    Cell Rep  2019;27:2837
  4. Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice.
    Authors: Albrengues Et al.
    Science  2018;361
  5. Neutrophil elastase-induced elastin degradation mediates macrophage influx and lung injury in 60% O2-exposed neonatal rats.
    Authors: Masood Et al.
    Am J Physiol Lung Cell Mol Physiol  2015;309:L53
  6. Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain.
    Authors: Saadoun Et al.
    J Neurosci  2012;71:323

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