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SJ 6986

Catalog #: 7720 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7720/10
7720/50
SJ 6986 | CAS No. 2765625-93-0 | Molecular Glues
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Description: Molecular glue; induces degradation of GSPT1/2

Chemical Name: N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide

Purity: ≥98%

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Biological Activity

SJ 6986 is a potent and selective GSPT1/2 molecular glue Degrader (DC50 = 2.1 nM). The Degrader exhibits antiproliferative effects in human medulloblastoma and leukemia cell lines. (EC50 values are 0.4 nM, 1.5 nM, 336 nM, 726 nM and 3583 nM in MHH-CALL-4, MV4-11, MB004, MB002 and HD-MB03 cell lines, respectively). In vivo, SJ 6986 is stable in mouse (t1/2 = 4.7 h). This product is orally bioavailable.

Technical Data

M.Wt:
497.4
Formula:
C20H14F3N3O7S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2765625-93-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from St. Jude Children's Research Hospital.

Product Datasheets

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